Front Cover: Development of a Palladium‐Catalyzed Process for the Synthesis of Z‐Alkenes by Sequential Sonogashira–Hydrogenation Reaction (Eur. J. Org. Chem. 38/2018)

Abstract

The Front Cover shows a conveyer belt with an internal alkyne made from a Sonogashira reaction in the moment when it is reacting to a bend Z‐alkene. One side of the hammer symbolizes the tool for the Sonogashira reaction, the other side represents the heterogeneous catalyst giving Z‐alkenes in high selectivity. This one‐pot, two‐step reaction is a rare example in which the homogeneous Sonogashira catalyst can be transformed in situ into a heterogeneous hydrogenation catalyst by adding water and warming up the reaction mixture to 120°C. 18 Z‐Alkenes were isolated in good to mediocre yields by using this method (34–86%). More information can be found in the https://doi.org/10.1002/ejoc.201800651