Front Cover: In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell‐Induced Photoreceptor Survival

Abstract

DOI: https://doi.org/10.1002/pmic.201800213 In article number https://doi.org/10.1002/pmic.201800213, Jones et al. identify mechanisms during human neural progenitor cell (hNPC) treatment of retinal degenerate rodents. Functional organization and anatomical connectivity of retina are highly complex and synchronized like an orchestra. As the retinal degeneration advances, photoreceptors are lost, whereas hNPC treatment slows the progression of degeneration and photoreceptors are preserved, as represented by the photoreceptor notes of the musical staff and corresponding histological staining of retinas. Proteomic analysis of hNPC treated tissue detects decreases in cell death, increases in cell survival, and the NRF2‐mediated response as a potential mechanism for photoreceptor preservation.