Front Cover: Longibramides A–E, Peptaibols Isolated from a Mushroom Derived Fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1 (Chem. Biodiversity 5/2021)

Abstract

Front Cover. Five new peptaibols, longibramides A – E (1–5) with 11 amino acid residues, were isolated from a fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, which was isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm collected from coniferous forest in the subboreal area of northeast China. The structures of longibramides A – E were determined by their spectroscopic data (NMR and MS‐MS spectra), their absolute configurations were determined by X‐ray diffractions and Marfey's analyses. The X‐ray diffractions of longibramides A, B and the similar CD spectra of A – E showed that they all had α‐helix conformations. Longibramides B and E showed moderate cytotoxicities against BV2 and MCF‐7 cells, and also showed some inhibitory effects against methicillin‐resistant Staphylococcus aureus MRSA T144. This result enriched the family of peptaibol, as reported by Zhang et al. in their full paper at10.1002/cbdv.202100128.