Front Cover Picture: Zincate‐Mediated Remote Functionalisation of p‐Iodobenzyl Derivatives Through Metallotropy in 2‐Methyltetrahydrofuran as Key Solvent (Adv. Synth. Catal. 22/2022)

Abstract

The front cover picture illustrates the 1,5‐rearrangement of lithium benzyl(dibutyl)zincate derived from p‐iodobenzyl mesylate. This key elementary step is integral to a complex reaction sequence allowing the remote functionalisation of such a derivative with a wide range of aldehydes (see fruits in the tree). As a remote leaving group (here OMs) is required to trigger the chemical event, the release of LiOMs can be seen as a driving force (LiOMs is thus the driver of the boat). Details can be found in the Research Article by Alexandre Vasseur and co‐workers (A. Pierret, C. Denhez, P. C. Gros, A. Vasseur, Adv. Synth. Catal. 2022, 364, 3805–3816; DOI: 10.1002/adsc.202200475).