Frontal functional connectivity and disease duration interactively predict cognitive decline in Parkinson's disease

Sánchez-Dinorín, Gerardo; Rodríguez-Violante, Mayela; Cervantes-Arriaga, Amín; Navarro-Roa, Cassandra; Ricardo-Garcell, Josefina; Rodríguez-Camacho, Mario; Solís-Vivanco, Rodolfo

doi:10.1016/j.clinph.2020.11.035

Cited by 14 publications

(13 citation statements)

References 59 publications

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“…Notably, Nissim et al found that paired active-transcranial direct current stimulation (tDCS) over the left DLPFC together with cognitive training significantly increased working memory performance, as well as functional connectivity between the left DLPFC and right inferior parietal lobule in older adults ( Nissim et al, 2019 ), which may also indicate that the DLPFC connectivity pattern plays a crucial role in cognitive function. On the other hand, our results also corroborate previous studies of changed functional connectivity in patients with PD that is related to their cognitive impairments ( Bertrand et al, 2016 ; Hassan et al, 2017 ; Chaturvedi et al, 2019 ; Sanchez-Dinorin et al, 2021 ). Among them, Hassan et al demonstrated that lower edge-wise connectivity in the alpha1 and alpha2 frequencies was associated with lower cognitive state, particularly in the frontotemporal areas ( Hassan et al, 2017 ).…”

Section: Discussionsupporting

confidence: 92%

“…The performances of visuospatial and attention functions are associated with PMFG-based functional connectivity. These findings confirm the discoveries of a recent study: increased frontal synchronization of slow oscillations predicts global cognitive and visuospatial functions ( Sanchez-Dinorin et al, 2021 ). In addition, another study found that attention and memory correlated significantly with the phase lag index in the beta and theta frequency bands, respectively ( Chaturvedi et al, 2019 ).…”

Section: Discussionsupporting

confidence: 92%

“…Electroencephalography functional connectivity could make a meaningful contribution to this procedure, given that altered signal rhythms in PD-MCI patients are related to underlying neuropathological changes ( Geraedts et al, 2018 ). Several studies have reported alterations in functional connectivity in patients with PD compared with healthy controls, and these abnormalities are exacerbated by cognitive impairments ( Bertrand et al, 2016 ; Sanchez-Dinorin et al, 2021 ). The PD-MCI patients in the current study had stronger brain-wide functional connectivity in the theta frequency band compared with PD-NC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, Hassan et al demonstrated that lower edge-wise connectivity in the alpha1 and alpha2 frequencies was associated with lower cognitive state, particularly in the frontotemporal areas ( Hassan et al, 2017 ). While another study using the phase-locking value found enhanced functional connectivity within the frontal regions over all frequency bands, and changes in the delta and theta frequency bands were associated with poorer cognitive performance in PD patients ( Sanchez-Dinorin et al, 2021 ). Indicators of functional connectivity determined by different algorithms may disclose different underlying neural mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Identifying Mild Cognitive Impairment in Parkinson’s Disease With Electroencephalogram Functional Connectivity

Cai

et al. 2021

Front. Aging Neurosci.

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ObjectiveCognitive impairment occurs frequently in Parkinson’s disease (PD) and negatively impacts the patient’s quality of life. However, its pathophysiological mechanism remains unclear, hindering the development of new therapies. Changes in brain connectivity are related to cognitive impairment in patients with PD, with the dorsolateral prefrontal cortex (DLPFC) being considered the essential region related to PD cognitive impairment. Nevertheless, few studies have focused on the global connectivity responsible for communication with the DLPFC node, the posterior division of the middle frontal gyrus (PMFG) in patients with PD; this was the focus of this study.MethodsWe applied resting-state electroencephalography (EEG) and calculated a reliable functional connectivity measurement, the debiased weighted phase lag index (dWPLI), to examine inter-regional functional connectivity in 68 patients with PD who were classified into two groups according to their cognitive condition.ResultsWe observed that altered left and right PMFG-based functional connectivity associated with cognitive impairment in patients with PD in the theta frequency bands under the eyes closed condition (r = −0.426, p < 0.001 and r = −0.437, p < 0.001, respectively). Exploratory results based on the MoCA subdomains indicated that poorer visuospatial function was associated with higher right PMFG-based functional connectivity (r = −0.335, p = 0.005), and poorer attention function was associated with higher left and right PMFG-based functional connectivity (r = −0.380, p = 0.001 and r = −0.256, p = 0.035, respectively). Further analysis using logistic regression and receiver operating characteristic (ROC) curves found that this abnormal functional connectivity was an independent risk factor for cognitive impairment [odds ratio (OR): 2.949, 95% confidence interval (CI): 1.294–6.725, p = 0.01 for left PMFG; OR: 11.278, 95% CI: 2.578–49.335, p = 0.001 for right PMFG, per 0.1 U], and provided moderate classification power to discriminate between cognitive abilities in patients with PD [area under the ROC curve (AUC) = 0.770 for left PMFG; AUC = 0.809 for right PMFG].ConclusionThese preliminary findings indicate that abnormal PMFG-based functional connectivity patterns associated with cognitive impairment in the theta frequency bands under the eyes closed condition and altered functional connectivity patterns have the potential to act as reliable biomarkers for identifying cognitive impairment in patients with PD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Identifying Mild Cognitive Impairment in Parkinson’s Disease With Electroencephalogram Functional Connectivity

Cai

et al. 2021

Front. Aging Neurosci.

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“…Put differently, our findings suggest that the differences in cognition evident in PD are more strongly driven by differences in topological robustness, rather than by more basic topological network attributes or simple functional connectivity differences 24 . It was previously also found that after a prolonged period of disease (i.e., eight years), hyperconnectivity in frontal brain regions, revealed via analysis of electroencephalogram (EEG) data, can be a predictor of cognitive decline in PD 59 . However, methodological differences in comparison with the present study (including the use of different imaging modalities and large difference in disease duration) may preclude direct comparisons.…”

Section: Discussionmentioning

confidence: 99%

Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson’s disease

et al. 2021

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Though Parkinson’s disease is primarily defined as a movement disorder, it is also characterized by a range of non-motor symptoms, including cognitive decline. The onset and progression of cognitive decline in individuals with Parkinson’s disease is variable, and the neurobiological mechanisms that contribute to, or protect against, cognitive decline in Parkinson’s disease are poorly understood. Using resting-state functional magnetic resonance imaging data collected from individuals with Parkinson’s disease with and without cognitive decline, we examined the relationship between topological brain-network resilience and cognition in Parkinson’s disease. By leveraging network attack analyses, we demonstrate that relative to individuals with Parkinson’s disease experiencing cognitive decline, the frontoparietal network in cognitively stable individuals with Parkinson’s disease is significantly more resilient to network perturbation. Our findings suggest that the topological robustness of the frontoparietal network is associated with the absence of cognitive decline in individuals with Parkinson’s disease.

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Functional Brain Dysconnectivity in Parkinson's Disease: A 5‐Year Longitudinal Study

et al. 2022

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Background Tracking longitudinal functional brain dysconnectivity in Parkinson's disease (PD) is a key element to decoding the underlying physiopathology and understanding PD progression. Objectives The objectives of this follow‐up study were to explore, for the first time, the longitudinal changes in the functional brain networks of PD patients over 5 years and to associate them with their cognitive performance and the lateralization of motor symptoms. Methods We used a 5‐year longitudinal cohort of PD patients (n = 35) who completed motor and non‐motor assessments and sequent resting state (RS) high‐density electroencephalography (HD‐EEG) recordings at three timepoints: baseline (BL), 3 years follow‐up (3YFU) and 5 years follow‐up (5YFU). We assessed disruptions in frequency‐dependent functional networks over the course of the disease and explored their relation to clinical symptomatology. Results In contrast with HC (n = 32), PD patients showed a gradual connectivity impairment in α2 (10‐13 Hz) and β (13–30 Hz) frequency bands. The deterioration in the global cognitive assessment was strongly correlated with the disconnected networks. These disconnected networks were also associated with the lateralization of motor symptoms, revealing a dominance of the right hemisphere in terms of impaired connections in the left‐affected PD patients in contrast to dominance of the left hemisphere in the right‐affected PD patients. Conclusions Taken together, our findings suggest that with disease progression, dysconnectivity in the brain networks in PD can reflect the deterioration of global cognitive deficits and the lateralization of motor symptoms. RS HD‐EEG may be an early biomarker of PD motor and non‐motor progression. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

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Frontal functional connectivity and disease duration interactively predict cognitive decline in Parkinson's disease

Cited by 14 publications

References 59 publications

Identifying Mild Cognitive Impairment in Parkinson’s Disease With Electroencephalogram Functional Connectivity

Identifying Mild Cognitive Impairment in Parkinson’s Disease With Electroencephalogram Functional Connectivity

Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson’s disease

Functional Brain Dysconnectivity in Parkinson's Disease: A 5‐Year Longitudinal Study

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