Frontal tDCS modulates orbitofrontal reality filtering

Manuel, Aurélie L.; David, Alexander; Bikson, Marom; Schnider, Armin

doi:10.1016/j.neuroscience.2014.01.052

Cited by 29 publications

(27 citation statements)

References 50 publications

(67 reference statements)

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“…For example, if hallucinated voices and inserted thoughts share a similar disturbance in executive control then both may benefit from specific treatments targeting this process. Recent evidence suggests, for instance, that transcranial direct current stimulation could be useful for modulating the process of reality filtering (Manuel et al 2014), offering a potentially new approach to the treatment of both AVH and TI.…”

Section: Summary and Implicationsmentioning

confidence: 99%

A Neuropsychological Approach to Auditory Verbal Hallucinations and Thought Insertion - Grounded in Normal Voice Perception

Badcock

2015

Rev.Phil.Psych.

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A neuropsychological perspective on auditory verbal hallucinations (AVH) links key phenomenological features of the experience, such as voice location and identity, to functionally separable pathways in normal human audition. Although this auditory processing stream (APS) framework has proven valuable for integrating research on phenomenology with cognitive and neural accounts of hallucinatory experiences, it has not yet been applied to other symptoms presumed to be closely related to AVH – such as thought insertion (TI). In this paper, I propose that an APS framework offers a useful way of thinking about the experience of TI as well as AVH, providing a common conceptual framework for both. I argue that previous self-monitoring theories struggle to account for both the differences and similarities in the characteristic features of AVH and TI, which can be readily accommodated within an APS framework. Furthermore, the APS framework can be integrated with predictive processing accounts of psychotic symptoms; makes predictions about potential sites of prediction error signals; and may offer a template for understanding a range of other symptoms beyond AVH and TI.Electronic supplementary materialThe online version of this article (doi:10.1007/s13164-015-0270-3) contains supplementary material, which is available to authorized users.

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Section: Summary and Implicationsmentioning

confidence: 99%

A Neuropsychological Approach to Auditory Verbal Hallucinations and Thought Insertion - Grounded in Normal Voice Perception

Badcock

2015

Rev.Phil.Psych.

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“…Moreover, more recent neuroimaging and evoked potential investigations have particularly pinpointed damage within the ventro-medial and/or orbito-frontal brain regions (Schnider, 2003;Gilboa et al, 2006;Toosy et al, 2008;Turner, Cipolotti, Yousry, & Shallice, 2008;Gilboa & Verfaellie, 2010;Nahum, Bouzerda-Wahlen, Guggisberg, Ptak, & Schnider, 2012;Hebscher, Barkan-Abramski, Goldsmith, Aharon-Peretz, & Gilboa, 2015;Schnider et al, 2013;Manuel, David, Bikson, & Schnider, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Schnider and colleagues have claimed that TCC (Schnider et al, 2000) or reality monitoring (Nahum et al, 2012) is the only correlate of both the presence and clinical course of confabulation (Schnider et al 2000;Schnider et al, 2013;Manuel et al, 2014). Temporal…”

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confidence: 99%

Confabulation: What is associated with its rise and fall? A study in brain injury

Bajo

Fleminger

Metcalfe

et al. 2017

Cortex

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The aim of this study was to investigate cognitive and emotional factors associated with the presence and clinical course of confabulation.24 confabulating participants were compared with 11 brain injured and 6 healthy controls on measures of temporal context confusions, mood state (elation, depression) and lack of insight.Measures of autobiographical memory and executive function were also available. Changes in confabulation and these other measures were monitored over 9 months in the confabulating group.We found that temporal context confusions were more common in confabulating patients than in healthy controls, and that the decline in these errors paralleled the recovery from confabulation.However, temporal context confusions were not specific to the presence of confabulation in brain injury; and their decline was not correlated with change in confabulation scores over 9 months.We found that elated mood and lack of insight discriminated between confabulating and nonconfabulating patients, but these measures did not correlate with either the severity of confabulation or change in confabulation scores through time. What seems to have been most strongly associated with the severity of confabulation scores at 'baseline' and changes through time (over 9 months) were the severity of memory impairment (especially on autobiographical memory) and errors on executive tests (particularly in making cognitive estimates). Greater autobiographical memory and executive impairment were associated with more severe confabulation.The findings were consistent with the view that confabulation results from executive dysfunction where autobiographical memory is also impaired; and that it resolves as these impairments subside.

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“…In the present study, tDCS was applied over the aPFC (Karim et al 2010;Chib et al 2013;Manuel et al 2014) during a probabilistic reinforcement learning task (Frank et al 2004;Frank 2005;Wheeler and Fellows 2008) with the aim to investigate the causal role of this area in (1) probabilistic reinforcement learning, (2) trial-by-trial behavioral adaptation in response to positive/negative feedback, and (3) decision-making under uncertainty.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation (tDCS) of the Anterior Prefrontal Cortex (aPFC) Modulates Reinforcement Learning and Decision-Making Under Uncertainty: a Double-Blind Crossover Study

et al. 2017

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Reinforcement learning refers to the ability to acquire information from the outcomes of prior choices (i.e. positive and negative) in order to make predictions on the effect of future decision and adapt the behaviour basing on past experiences. The anterior prefrontal cortex (aPFC) is considered to play a key role in the representation of event value, reinforcement learning and decision-making. However, a causal evidence of the involvement of this area in these processes has not been provided yet. The aim of the study was to test the role of the orbitofrontal cortex in feedback processing, reinforcement learning and decision-making under uncertainly. Eighteen healthy individuals underwent three sessions of tDCS over the prefrontal pole (anodal, cathodal, sham) during a probabilistic learning (PL) task. In the PL task, participants were invited to learn the covert probabilistic stimulusoutcome association from positive and negative feedbacks in order to choose the best option. Afterwards, a probabilistic selection (PS) task was delivered to assess decisions based on the stimulus-reward associations acquired in the PL task. During cathodal tDCS, accuracy in the PL task was reduced and participants were less prone to maintain their choice after positive feedback or to change it after a negative one (i.e., winstay and lose-shift behavior). In addition, anodal tDCS affected the subsequent PS task by reducing the ability to choose the best alternative during hard probabilistic decisions. In conclusion, the present study suggests a causal role of aPFC in feedback trial-by-trial behavioral adaptation and decision-making under uncertainty.

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Frontal tDCS modulates orbitofrontal reality filtering

Cited by 29 publications

References 50 publications

A Neuropsychological Approach to Auditory Verbal Hallucinations and Thought Insertion - Grounded in Normal Voice Perception

A Neuropsychological Approach to Auditory Verbal Hallucinations and Thought Insertion - Grounded in Normal Voice Perception

Confabulation: What is associated with its rise and fall? A study in brain injury

Transcranial Direct Current Stimulation (tDCS) of the Anterior Prefrontal Cortex (aPFC) Modulates Reinforcement Learning and Decision-Making Under Uncertainty: a Double-Blind Crossover Study

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