Frontal white matter integrity is related to psychomotor retardation in major depression

Walther, Sebastian; Hügli, Simone; Höfle, Oliver; Federspiel, Andrea; Horn, Helge; Bracht, Tobias; Wiest, Roland; Strik, Werner; Müller, Thomas

doi:10.1016/j.nbd.2012.03.019

Cited by 86 publications

(74 citation statements)

References 84 publications

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“…This is a low activity level compared with other studies that assessed psychomotor functioning in a somewhat younger population (45.0 years) with depressive symptoms (12,417 ± 6,285 counts per hour). Compared to the controls (41.0 years), the difference is even larger, with a daytime activity level of 19,599 (±7,050) counts per hour [45]. The depressed adults in another ECT population had an average activity level of 10,140 counts per hour, but they were somewhat younger than the patients in our sample (47.9 years) [46].…”

Section: Resultsmentioning

confidence: 81%

Distinguishing Subgroups Based on Psychomotor Functioning among Patients with Major Depressive Disorder

et al. 2017

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Background: Retardation and agitation are symptoms of major depressive disorder (MDD), and their presence could play a role in determining clinically meaningful depressive subtypes such as nonmelancholic depression (NMD) and melancholic depression (MD). In this project, we explored whether three depression subgroups (NMD, MD with psychotic symptoms, and MD without psychotic symptoms) could be distinguished based on objective measures of psychomotor functioning. Methods: Sixty-nine patients with MDD underwent extensive clinical and psychomotor testing prior to treatment with electroconvulsive therapy. Psychomotor functioning was assessed subjectively using the Core Assessment of Psychomotor Change (CORE) and objectively by means of both 24-h actigraphy and performance on a fine motor drawing task. Results: The daytime activity levels measured by actigraphy were significantly lower (F = 7.1, p = 0.0004) in MD patients both with and without psychotic symptoms than in those with NMD. No objective psychomotor variable was able to distinguish between melancholic patients with and those without psychotic symptoms. Conclusions: The depression subtypes NMD, MD with psychotic symptoms, and MD without psychotic symptoms are not marked by increasing psychomotor retardation, possibly because psychomotor disturbance in MD with psychotic symptoms often consists of agitation rather than retardation, or a mixture of the two. However, psychomotor functioning as measured by actigraphy can be used to distinguish between NMD patients and MD patients.

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Section: Resultsmentioning

confidence: 81%

Distinguishing Subgroups Based on Psychomotor Functioning among Patients with Major Depressive Disorder

et al. 2017

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“…Detailed demographics of our sample are given in Table 1. Data derived from the first MRI scan of MDD patients were used for group comparisons with healthy controls from previous studies that used an identical acquisition protocol Bracht et al, 2014c;Walther et al, 2012). The study was approved by the local ethics committee (KEK-BE 196/09) and in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

Limbic white matter microstructure plasticity reflects recovery from depression

Bracht

Jones

Müller

et al. 2015

Journal of Affective Disorders

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“…Hippocampal dysfunction and atrophy associates with mood disorders (Small et al, 2011), and in normal and neurodegenerative conditions, DTI measures of WM microstrucure of the hippocampal part of the cingulum bundle correlate with memory scores and hippocampal volume (Sexton et al, 2010). The cingulum bundle integrates disparate modular brain systems involved in attention, memory, and emotion regulation, and in mood disorders, a higher directionality of water diffusion in the cingulum bundle associates with better hedonic tone (Keedwell et al, 2012), better cognitive performance (Schermuly et al, 2010), and less psychomotor slowing (Walther et al, 2012). The number of fibers within the uncinate fasciculus inversely correlated with depression severity (Zhang et al, 2012).…”

Section: Lithium and Gsk3-b Effects On White Matter F Benedetti Et Almentioning

confidence: 99%

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

Benedetti

Bollettini

Barberi

et al. 2012

Neuropsychopharmacol

147

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Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-b (GSK3-b). The less active GSK3-b promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-b gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-b promoter rs334558 polymorphism on WM microstructure, using DTI and tract-based spatial statistics with threshold-free cluster enhancement. We report that the less active GSK3-b rs334558*C gene-promoter variants, and the long-term administration of the GSK3-b inhibitor lithium, were associated with increases of DTI measures of axial diffusivity (AD) in several WM fiber tracts, including corpus callosum, forceps major, anterior and posterior cingulum bundle (bilaterally including its hippocampal part), left superior and inferior longitudinal fasciculus, left inferior fronto-occipital fasciculus, left posterior thalamic radiation, bilateral superior and posterior corona radiata, and bilateral corticospinal tract. AD reflects the integrity of axons and myelin sheaths. We suggest that GSK3-b inhibition and lithium could counteract the detrimental influences of BD on WM structure, with specific benefits resulting from effects on specific WM tracts contributing to the functional integrity of the brain and involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections.

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Frontal white matter integrity is related to psychomotor retardation in major depression

Cited by 86 publications

References 84 publications

Distinguishing Subgroups Based on Psychomotor Functioning among Patients with Major Depressive Disorder

Distinguishing Subgroups Based on Psychomotor Functioning among Patients with Major Depressive Disorder

Limbic white matter microstructure plasticity reflects recovery from depression

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

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