Frontispiece: Recent Advances in Functional Polymer Decorated Two‐Dimensional Transition‐Metal Dichalcogenides Nanomaterials for Chemo‐Photothermal Therapy

Abstract

The combination of chemotherapy with photothermal therapy into one system for tumor therapy is an effective strategy to further improve the therapy efficiency. In this Minireview, the focus is set on the most recent significant developments in constructing photothermal and chemical combined therapeutics by integrating two‐dimensional transition metal dichalcogenides nanomaterials and functional polymers. The design of materials and formulations to integrating with stimuli‐responsive polymer modules is highlighted in particular. For more details, see J. Liu et al. on page 4215 ff.

Multifunctional HNT@Fe3O4@PPy@DOX Nanoplatform for Effective Chemo-Photothermal Combination Therapy of Breast Cancer with MR Imaging

“…Photothermal therapy (PTT) is an effective treatment in cancer that converts near-infrared (NIR) light energy into heat through a photothermal agent, which leads to a rapid increase of temperature in tumor sites . More and more evidence from reported research reveals that cancer cells are more sensitive to PTT than normal cells. , PTT has the advantages of high temporal and spatial resolution, safety, high efficiency, and noninvasiveness. , However, PTT cannot completely inhibit tumor growth because of the uneven heat distribution and heat resistance during irradiation. , In order to achieve better therapeutic effects toward tumor, researchers have extensively studied combinations with photodynamic therapy, , chemotherapy, , gene therapy, , or immunotherapy . In these methods, nanomaterial platform designed with the combination of diagnosis and therapy is significant because the nanomaterials can amplify the anticancer efficiency. , …”

“…4,5 However, PTT cannot completely inhibit tumor growth because of the uneven heat distribution and heat resistance during irradiation. 6,7 In order to achieve better therapeutic effects toward tumor, researchers have extensively studied combinations with photodynamic therapy, 8,9 chemotherapy, 10,11 gene therapy, 12,13 or immunotherapy. 14 In these methods, nanomaterial platform designed with the combination of diagnosis and therapy is significant because the nanomaterials can amplify the anticancer efficiency.…”