Fronto-Striatal Cognitive Deficits at Different Stages of Parkinson's Disease

Owen, Adrian M.; James, Merle; Leigh, P. Nigel; Summers, Beatrice A.; Marsden, C. D.; Quinn, Niall; Lange, Klaus W.; Robbins, Trevor W.

doi:10.1093/brain/115.6.1727

Cited by 819 publications

(590 citation statements)

References 48 publications

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“…Our finding of impaired task performance is in agreement with previous studies on planning in PD [Muslimović et al, 2005; Owen et al, 1998, 1992]. In contrast to our hypothesis and the findings of Muslimović et al [2009], however, we found similar performance decline over time in both patients and controls.…”

Section: Discussionsupporting

confidence: 92%

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Trujillo

Gerrits

Vriend

et al. 2015

Human Brain Mapping

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ObjectiveParkinson's disease (PD) often entails impairments of executive functions, such as planning. Although widely held that these impairments arise from dopaminergic denervation of the striatum, not all executive functions are affected early on, and the underlying neural dynamics are not fully understood. In a combined longitudinal and cross‐sectional study, we investigated how planning deficits progress over time in the early stages of PD compared to matched healthy controls. We used functional magnetic resonance imaging (fMRI) to identify accompanying neural dynamics.MethodsSeventeen PD patients and 20 healthy controls performed a parametric Tower of London task at two time points separated by ∼3 years (baseline and follow‐up). We assessed task performance longitudinally in both groups; at follow‐up, a subset of participants (14 patients, 19 controls) performed a parallel version of the task during fMRI. We performed meta‐analyses to localize regions‐of‐interest (ROIs), that is, the bilateral dorsolateral prefrontal cortex (DLPFC), inferior parietal cortex, and caudate nucleus, and performed group‐by‐task analyses and within‐group regression analyses of planning‐related neural activation. We studied task‐related functional connectivity of seeds in the DLPFC and caudate nucleus.ResultsPD patients, compared with controls, showed impaired task performance at both time‐points, while both groups showed similar performance reductions from baseline to follow‐up. Compared to controls, patients showed lower planning‐related brain activation together with decreased functional connectivity.ConclusionThese findings support the notion that planning is affected early in the PD disease course, and that this impairment in planning is accompanied by decreases in both task‐related brain activity and connectivity. Hum Brain Mapp 36:3703–3715, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 92%

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Trujillo

Gerrits

Vriend

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

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“…The number of between-search errors (errors made when the subject revisits a box in which a token has previously been found) and a strategy score derived from the number of search sequences in the four, six, and eight boxes were used as performance indexes. The strategy score retraced the 'route' previously used by subjects in searching through the spatial array of boxes (Owen et al, 1992;Robbins, 1996). One possible strategy was to follow a predetermined sequence, beginning with a particular box and then returning to start each new sequence with the same box as soon as a token was found.…”

Section: Neuropsychological Assessmentsmentioning

confidence: 99%

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

Capuron

Welberg

Heim

et al. 2006

Neuropsychopharmacol

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Patients with chronic fatigue syndrome (CFS) frequently complain of cognitive dysfunction. However, evidence of cognitive impairment in CFS patients has been found in some, but not other, studies. This heterogeneity in findings may stem from the relative presence of mental fatigue in the patient populations examined. The present study assessed this possibility in a population-based sample of CFS patients. In all, 43 patients with CFS defined by the criteria of the 1994 research case definition using measurements recommended by the 2003 International CFS Study Group, and 53 age-, sex-, and race/ethnicity-matched nonfatigued subjects were included in the study. Mental fatigue was assessed using the mental fatigue subscale of the multidimensional fatigue inventory. Cognitive function was evaluated using an automated battery of computerized tests (Cambridge neuropsychological test automated battery (CANTAB)) that assessed psychomotor function, planning and problem-solving abilities, and memory and attentional performance. CFS patients with significant complaints of mental fatigue (score of mental fatigue 2 standard deviations above the mean of nonfatigued subjects) exhibited significant impairment in the spatial working memory and sustained attention (rapid visual information processing) tasks when compared to CFS patients with low complaints of mental fatigue and nonfatigued subjects. In CFS patients with significant mental fatigue, sustained attention performance was impaired only in the final stages of the test, indicating greater cognitive fatigability in these patients. CFS patients with low mental fatigue displayed performance comparable to nonfatigued subjects on all tests of the CANTAB battery. These findings show strong concordance between subjective complaints of mental fatigue and objective measurement of cognitive impairment in CFS patients and suggest that mental fatigue is an important component of CFS-related cognitive dysfunction.

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“…PD is characterized by striatal DA depletion and is accompanied by cognitive deficits from the earliest disease stages (Owen et al, 1992). The DA depletion progresses from the dorsal to the ventral striatum, so that, in early PD, the dorsal striatum is severely depleted, but the ventral striatum is relatively intact (Farley et al, 1977;Kish et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

Cools

Lewis

Clark

et al. 2006

Neuropsychopharmacol

268

210

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Evidence indicates that dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used functional magnetic resonance imaging in patients with mild Parkinson's disease to investigate the neural site at which L-DOPA acts during reversal learning. Patients were scanned both ON and OFF their normal dopamine-enhancing L-DOPA medication during the performance of a probabilistic reversal learning task. We demonstrate that L-DOPA modulated reversal-related activity in the nucleus accumbens, but not in the dorsal striatum or the prefrontal cortex. These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning.

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Fronto-Striatal Cognitive Deficits at Different Stages of Parkinson's Disease

Cited by 819 publications

References 48 publications

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

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