Frozen blastocyst embryo transfer vs. frozen cleavage-stage embryo transfer in couples with recurrent implantation failure: a cohort study

Zhang, Xiaodong; Gao, Yang; Liu, Weiwei; Liu, Junxia; Wu, Lie; Xiong, Shun; Zhu, Jiahong; Han, Wei; Wang, Jiang; Hao, Xiangwei; Han, Shubiao; Huang, Gangliang

doi:10.1080/14647273.2019.1633021

Cited by 17 publications

(10 citation statements)

References 21 publications

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“…Our real-world study showed that implantation rates during FET were signi cantly higher with SBT than Day 3 DET (50.1% versus 37.6%, p < 0.05), which was in line with evidence in the literature which showed SBT to have better implantation rate than Day 3 DET [1,11,12]. This may be attributed to better quality embryos if embryo cultures are maintained until Day 5 [3,4].…”

Section: Discussionsupporting

confidence: 89%

A retrospective comparative study of double cleavage-stage embryo transfer versus single blastocyst in frozen-thawed cycles

Lim,

Sim,

Nadkarni

2023

Preprint

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Background This retrospective study aimed to compare the outcomes of Day 3 double embryo transfer (DET) with single blastocyst transfer (SBT) during frozen embryo transfer (FET) cycles. A total of 999 women below the age of 38 years who underwent FET at Malaysia’s KL Fertility & Gynaecology Centre from January 2019 to December 2021 were analysed. Patients with autologous eggs were recruited in the study. All the eggs were inseminated by intracytoplasmic sperm injection. The embryos were vitrified on Day 3 cleavage-stage or blastocyst stage with Cryotop® method. The FET were performed following natural cycle (NC), modified natural cycle (m-NC) or hormone replacement therapy (HRT) cycles. The NC and m-NC groups received oral dydrogesterone for luteal phase support. Results There were no statistical differences in the rates of positive pregnancy, clinical pregnancy and ongoing pregnancy between the two groups. However, implantation rates were significantly higher in the SBT group (50.1% versus 37.6%, p < 0.05). The Day 3 DET group had significantly higher multiple pregnancy rates (28.7% versus 1.1%, p < 0.05). Subgroup analysis of embryo transfers performed following NC, m-NC or HRT cycles showed similar results. Conclusions This study suggests that SBT is the better choice for embryo transfers as it had higher implantation rates and its pregnancy rates were similar to Day 3 DET. The SBT also significantly reduced the incidence of multiple pregnancies without compromising pregnancy rates.

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Section: Discussionsupporting

confidence: 89%

A retrospective comparative study of double cleavage-stage embryo transfer versus single blastocyst in frozen-thawed cycles

Lim,

Sim,

Nadkarni

2023

Preprint

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“…As is generally accepted that the potential and possibility of blastocysts fertilized and developed are superior to cleavage embryos. A cohort study also found that the CPR, IR, and ongoing pregnancy rate were higher in the frozen‐thawed single blastocyst‐stage transfer group compared with the double cleavage‐stage embryo transfer (41.15% vs 27.11%, P < .001; 41.15% vs 19.28%, P < .001; 40.03% vs 25.9%, P < .001) 35 . Conventional wisdom holds the view that the health of the oocyte and the euploid of the embryo are the most key factors in fertility.…”

Section: Discussionmentioning

confidence: 91%

“…tilized and developed are superior to cleavage embryos. A cohort study also found that the CPR, IR, and ongoing pregnancy rate were higher in the frozen-thawed single blastocyst-stage transfer group compared with the double cleavage-stage embryo transfer (41.15% vs 27.11%, P < .001; 41.15% vs 19.28%, P < .001; 40.03% vs 25.9%, P < .001) 35.…”

mentioning

confidence: 91%

Improved pregnancy outcomes of cyclosporine A on patients with unexplained repeated implantation failure in IVF/ICSI cycles: A retrospective cohort study

Cheng

et al. 2022

American J Rep Immunol

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Problem: Repeated implantation failure (RIF) is a daunting obstacle restricting the further improvement of embryo implantation rate (IR) and live birth rate (LBR). The beneficial effect of cyclosporine A (CsA) on reproductive outcomes of unexplained RIF(URIF) was explored after de novo embryo transfer (ET). Method of study:A retrospective cohort study was conducted, comparing pregnancy outcomes of 146 cycles (CsA group, n = 62; control group, n = 84) at the IVF center of

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“…During the last decades, a variety of therapeutic approaches and interventions have been proposed to manage poor responsiveness to in vitro fertilization techniques, including uterine interventions [ 48 , 49 , 50 , 51 , 52 ], gynecological surgical procedures [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ], immunomodulatory therapies [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ] or treatments to enhance endometrial receptivity [ 69 , 70 , 71 , 72 , 73 ]. However, it was not until 2015 [ 8 ] that autologous platelet concentrates were used to promote endometrial growth and improve pregnancy outcome in infertile women with TE.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

et al. 2023

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Assisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich plasma (PRP) therapies use a patient’s own platelets to promote tissue healing and growth, including endometrium. The growth factors provided by the platelets play a criterial role on the regenerative ability of PRP. In the last years, PRP treatments have been gaining a lot of popularity to treat women with repeated ART failures. In this study, we collected and summarized all information published in the scientific literature to assess the evidence of the PRP effect on pregnancy. We only considered randomized controlled trials (RCT), a type of study designed to be unbiased and considered at the highest level of evidence. Our analysis indicates that PRP therapies might be an effective treatment in cases of poor responsiveness to conventional ART. However, additional studies (well-designed) are necessary to confirm this beneficial effect of PRP.

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Frozen blastocyst embryo transfer vs. frozen cleavage-stage embryo transfer in couples with recurrent implantation failure: a cohort study

Cited by 17 publications

References 21 publications

A retrospective comparative study of double cleavage-stage embryo transfer versus single blastocyst in frozen-thawed cycles

A retrospective comparative study of double cleavage-stage embryo transfer versus single blastocyst in frozen-thawed cycles

Improved pregnancy outcomes of cyclosporine A on patients with unexplained repeated implantation failure in IVF/ICSI cycles: A retrospective cohort study

Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

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