Fructose Activates a Stress Response Shared by Methylglyoxal and Hydrogen Peroxide inStreptococcus mutans
Alejandro R. Walker,
Danniel N. Pham,
Payam Noeparvar
et al.
Abstract:Fructose catabolism by Streptococcus mutans is initiated by three PTS transporters yielding either fructose-1-phoshate (F-1-P) or fructose-6-phosphate (F-6-P). Deletion of one such F-1-P-generating PTS, fruI, has been shown to reduce the cariogenicity of S. mutans in rats fed a high-sucrose diet. Moreover, a recent study linked fructose metabolism in S. mutans to a reactive electrophile species (RES) methylglyoxal. Here, we conducted a comparative transcriptomic analysis of exponentially grown S. mutans shocke… Show more
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