Fructose: Toxic effect on cardiorenal risk factors and redox state

Abstract

Aim:To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal.Methods:Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed.Results:Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group.Conclusion:Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.

High-Fat-High-Fructose Diet Decreases Hippocampal Neuron Number in Male Rats

“…The intake of drink containing fructose is thought to be the cause of the low intake, as it has been suggested that the intake of fructose Discussion drink could suppress solid food intakes. (17) Low feed intake is also influenced by rat feed factors. Rats prefer food that is dry, solid, coarse texture, and hard in consistency (18), whereas the AIN-93M modified HFHF diet tended to be oily and slightly soft due to its high fat content (51.64%).…”

Amelioration of Abnormalities Associated with the Metabolic Syndrome by Spinacia oleracea (Spinach) Consumption and Aerobic Exercise in Rats

“…Fructose has been implicated as a contributor to nearly all of the classic manifestations of MetS. Increased fructose consumption can lead to hyperlipidemia, development of insulin resistance, inflammation, oxidative stress, obesity, and comorbidities such as hypertension and T2DM, all risk factors for cardiac dysfunction [ 6 ]. Hence, rats given free access to drinking water containing an excess of fructose exhibit all classical abnormalities associated with MetS.…”

“…Hence, rats given free access to drinking water containing an excess of fructose exhibit all classical abnormalities associated with MetS. Fructose-enriched diet has been shown to promote oxidative stress in rodents [ 6 ]. Moreover, oxidative stress has been closely related to cardiovascular diseases linked with diabetes [ 7 ].…”

Impact of combined exercise training on the development of cardiometabolic and neuroimmune complications induced by fructose consumption in hypertensive rats

“…It should be noted that the toxicity of fructose is directly related to the time of exposure to this sugar. In animals consuming fructose (30%) for 24 weeks an increase in oxidative stress was observed, whereas the group that stopped consuming fructose improved the parameters of oxidative stress [38]. Although fructose is metabolized in the liver, this does not exclude its deleterious effects on other organs such as the heart, kidneys and brain.…”