Fructus agni casti and bromocriptine for treatment of hyperprolactinemia and mastalgia

Kilicdag, EB; Tarım, Ebru; Bağış, Tayfun; Erkanli, Serkan; Aslan, Erdoğan; Özşahin, Kürşat; Kuşçu, Esra

doi:10.1016/j.ijgo.2004.01.001

Cited by 35 publications

(45 citation statements)

References 2 publications

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“…10 In conclusion, the prospective, randomised, double-blind, placebo-controlled, clinical trial in Chinese women has found that VAC BNO 1095 was more effective than placebo on almost all symptoms documented in PMSD for women with mild-to-severe PMS, especially on symptoms of negative effect. Perhaps it also reflected some characteristics of PMS in Chinese women.…”

Section: Discussionmentioning

confidence: 88%

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Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Lin

Chen

et al. 2010

Aust NZ J Obst Gynaeco

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Section: Discussionmentioning

confidence: 88%

“…Dopaminergic effects of the VAC BNO 1095 extract have been proven in animal and clinical trials. 10,11 Vitex agnus castus extract has been used in several placebo-controlled trials. [12][13][14][15][16] These studies confirmed that VAC relieves symptoms of the PMS without notable side effects.…”

Section: Introductionmentioning

confidence: 99%

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Lin

Chen

et al. 2010

Aust NZ J Obst Gynaeco

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“…It has a long history of use in the treatment of female reproductive conditions, and is still used today to treat premenstrual syndrome (PMS). The efficacy of crude fruit extracts for relieving symptoms of PMS and related syndromes is strongly supported by evidence from multiple clinical trials (Schellenberg, ; Atmaca et al ., ; He et al ., ), and include relief from latent hyperprolactinemia and cyclic mastalgia (Kilicdag et al ., ; Carmichael, ). In addition, extracts are considered to be safe and better tolerated than conventional hormone or selective serotonin reuptake inhibitor‐based treatments (Daniele et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus‐castus

et al. 2018

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Summary Vitex agnus‐castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. The pharmaceutical activity of the plant extract is linked to its ability to lower prolactin levels. This feature has been attributed to the presence of dopaminergic diterpenoids that can bind to dopamine receptors in the pituitary gland. Phytochemical analyses of V. agnus‐castus show that it contains an enormous array of structurally related diterpenoids and, as such, holds potential as a rich source of new dopaminergic drugs. The present work investigated the localisation and biosynthesis of diterpenoids in V. agnus‐castus. With the assistance of matrix‐assisted laser desorption ionisation‐mass spectrometry imaging (MALDI‐MSI), diterpenoids were localised to trichomes on the surface of fruit and leaves. Analysis of a trichome‐specific transcriptome database, coupled with expression studies, identified seven candidate genes involved in diterpenoid biosynthesis: three class II diterpene synthases (diTPSs); three class I diTPSs; and a cytochrome P450 (CYP). Combinatorial assays of the diTPSs resulted in the formation of a range of different diterpenes that can account for several of the backbones of bioactive diterpenoids observed in V. agnus‐castus. The identified CYP, VacCYP76BK1, was found to catalyse 16‐hydroxylation of the diol‐diterpene, peregrinol, to labd‐13Z‐ene‐9,15,16‐triol when expressed in Saccharomyces cerevisiae. Notably, this product is a potential intermediate in the biosynthetic pathway towards bioactive furan‐ and lactone‐containing diterpenoids that are present in this species.

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“…Комментарии Comments E. B. Kilicdag и со-авт., 2004 [19] E. B. Kilicdag et al, 2004 [19] 40 женщин с мастоди-нией и 40 -с латент-ной гиперпролактине-мией L. Ciotta и соавт., 2011 [21] L. Ciotta et al, 2011 [21] 57 женщин с ПМС Тяжесть симптомов ПМС…”

Section: Assessment Criteriaunclassified

Herbal Medicinal Products in a Treatment of Mastalgia in Gynecologic Patients

Кедрова¹,

Levakov²

2017

Tumors of female reproductive system

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ОПУХОЛИ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ TUMORS OF FEMALE REPRODUCTIVE SYSTEMВведение В последние годы повышенная информирован-ность общественности о раке молочной железы (РМЖ) и широкое применение маммографического скрининга привели к увеличению числа биопсий, вы-полняемых с целью оценки клинических или рентге-нологических изменений тканей молочной железы (МЖ), часто вызванных дисгормональными расстрой-ствами. Влияние гормональных нарушений имеет вы-раженное системное значение, встречается у 70 % женщин репродуктивного возраста и проявляется в виде предменструального синдрома (ПМС), дисфо-рических, вазомоторных и психических расстройств (табл. 1) [1].Одним из наиболее распространенных и пугающих женщин симптомов ПМС является боль в груди -предменструальная мастодиния (наблюдается почти у каждой 5-й женщины). Когда эта боль становится ярко выраженной, она классифицируется как мастал-гия (тяжелая мастодиния) [2,3]. Распространенность клинически значимой масталгии у женщин, проходя-щих ультразвуковой или рентгенологический скри-нинг РМЖ, составляет 69 % [1]. Ранняя диагностика и лечение масталгии всегда были важной задачей для акушеров-гинекологов, так как болевые ощуще-ния продолжительностью более 5 дней влияют на сек-суальную, соматическую и социальную жизнь паци-енток. Часто циклические изменения, вызывающие тяжесть в МЖ, связаны с латентной гиперпролакти-немией, которая характеризуется секреторными эпи-зодами высвобож дения пролактина гипофизом в от-вет на стресс и нарушения фазы глубокого сна [4].

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Fructus agni casti and bromocriptine for treatment of hyperprolactinemia and mastalgia

Cited by 35 publications

References 2 publications

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus‐castus

Herbal Medicinal Products in a Treatment of Mastalgia in Gynecologic Patients

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