Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats

Chen, Beibei; Wei, Junping; Zhu, Ruyuan; Zhang, Hao; Xia, Bingke; Liu, Yage; Xuan, Dong; Ye, Zimengwei; Tian, Yimiao; Li, Rui; Zhao, Dandan; Mo, Fangfang; Orekhov, Alexander N.; S, Gao; Brὂmme, Dieter; Wang, Lili; Zhang, Dongwei

doi:10.1016/j.jep.2021.114348

Cited by 19 publications

(9 citation statements)

References 43 publications

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“…On a yearly basis, several scientific investigations come out to demonstrate that, indeed, TCM formulae, herbs, and bioactive compounds exert their therapeutic outcomes by targeting several regulating several diseased biomolecules, hence improving health and alleviating disease ( Liu et al, 2014 ; Zhou et al, 2021 ). Similarly, studies have revealed that TCM formulae, herbs, and compounds also possess the ability to influence the activity of the VDR ( Kuai et al, 2020 ; Chen et al, 2021 ; Xiong et al, 2022 ). The discovery of VDR-modulating properties in TCM formulae components, herbs, and TCM compounds opens up new avenues to uncover novel therapeutic approaches for VDR-dependent human diseases, potentially offering safer and more effective treatment options.…”

Section: Therapeutic Applications Of Tcm and Bioactive Compounds In V...mentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

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The Vitamin D receptor (VDR) is a crucial nuclear receptor that plays a vital role in various physiological functions. To a larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin D or its synthetic analogs to treat non-communicable diseases is insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) and bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae and TCM-derived bioactive compounds have shown promise in modulating VDR activities. This review explores the intriguing potential of TCM and bioactive compounds in modulating VDR activity. We first emphasize the latest information on the genetic expression, function, and structure of VDR, providing a comprehensive understanding of this crucial receptor. Following this, we review several TCM formulae and herbs known to influence VDR alongside the mechanisms underpinning their action. Similarly, we also discuss TCM-based bioactive compounds that target VDR, offering insights into their roles and modes of action.

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Section: Therapeutic Applications Of Tcm and Bioactive Compounds In V...mentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

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“…The right femurs were subjected to the μ-CT scanning as previously described [31,32]. Briefly, the right femur was scanned and captured by the Quantum GX μCT instrument (PerkinElmer, USA).…”

Section: μ-Ct Scanningmentioning

confidence: 99%

“…After the μCT scanning, the right femurs were taken for a three-point bending assay by an electronic universal testing machine (Shimadzu Corporation, AGS-X500, Japan), as previously described [31,32]. The shaft of the femur was fixed between the two supporting points, with a distance of 20 mm.…”

Section: Bone Biomechanical Strength Assaymentioning

confidence: 99%

Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in OVX Rats and BMSCs

Xia,

Dai,

Shi

et al. 2024

Preprint

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Recent interest in preventing the development of osteoporosis has focused on the regulation of redox homeostasis. However, the action of lycopene (LYC), a strong natural antioxidant com-pound, on osteoporotic bone loss remains largely unknown. Here, we show that the administra-tion of LYC to OVX rats reduces body weight gain, improves lipid metabolism and preserves bone quality. In addition, LYC treatment inhibits ROS overgeneration in serum and bone marrow in OVX rats, and in BMSCs upon H2O2 stimulation, leading to inhibiting adipogenesis and pro-moting osteogenesis during bone remodeling. Mechanically, LYC may improve bone quality via an increase in the expressions of FoxO1 and Runx2, and a decrease in the expressions of PPARγ and C/EBPα in OVX rats and BMSCs. Collectively, these findings suggest that LYC attenuates osteoporotic bone loss through promoting osteogenesis and inhibiting adipogenesis via regula-tion of the FoxO1/PPARγ pathway driven by oxidative stress, presenting a novel strategy for os-teoporosis management.

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“…Therein, SCFAs are mainly produced by the bacterial fermentation of amino acids or indigestible carbohydrates in the colon, and its specific components include acetic acid, propionic acid, butyric acid, and so on, which is one of the most vital metabolites of intestinal beneficial bacteria in the process of FMT [71][72][73]. Furthermore, after performing FMT, the SCFAs may influence the process of bone metabolism via various mechanisms, including inhibiting inflammatory response, improving intestinal calcium absorption, promoting osteoblast differentiation via regulatory T cells (Tregs), directly inhibiting osteoclast differentiation, and so on [20,[74][75][76]. Yan et al [59] also highlighted in a previous study that SCFAs indirectly participate in the protection of bone mass by affecting the level of serum insulin-like growth factor-1 (IGF-1).…”

Section: The Involvement Of Intestinal Metabolitesmentioning

confidence: 99%

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Zhang

Cao

et al. 2022

J Bone Miner Metab

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Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel "organ transplantation" technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut-bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.

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Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats

Cited by 19 publications

References 43 publications

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in OVX Rats and BMSCs

Fecal microbiota transplantation as a promising treatment option for osteoporosis

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