Fruit fly research in China

Cheng, Ying; Chen, Dahua

doi:10.1016/j.jgg.2018.09.003

Cited by 2 publications

(2 citation statements)

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“…The fruit fly ( Drosophila melanogaster ) is a unique and powerful genetic model organism with a high degree of genetic conservatism and easy genome manipulation, and thus can be used to study a wide range of biological issues ( Cheng & Chen, 2018 ). Drosophila can help identify genes associated with ASD ( Hope et al, 2019 ).…”

Section: Common Animals Used In Asd Studymentioning

confidence: 99%

“…In contrast, heterozygous gKO and cKO mice are viable, indicating that all chromosome 1p21.3 microdeletion carriers are hemizygous. The partial loss of miR-137 in heterozygous gKO and cKO mice can cause synaptic overgrowth and impaired synaptic plasticity related to ASD, as well as impaired repetitive behaviors, learning, and social behaviors ( Cheng et al, 2018 ). Multi-omics studies have revealed that one of the miR-137 mRNA targets, phosphodiesterase 10a (Pde10a), is elevated in Mir137 -knockout mice, and the application of the Pde10a inhibitor papaverine or lentivirus-induced Pde10a knockdown significantly ameliorates the deficits observed in heterozygous Mir137 -knockout mice.…”

Section: Diverse Animal Models Exploring Key Features Of Asdmentioning

confidence: 99%

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Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Zhu

et al. 2021

Zoological Research

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Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its highly heterogeneous nature. To better understand the pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, and idiopathic animal models. In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models.

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Section: Common Animals Used In Asd Studymentioning

confidence: 99%

Section: Diverse Animal Models Exploring Key Features Of Asdmentioning

confidence: 99%