Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

Kubatka, Peter; Kapinová, Andrea; Kello, Martin; Kružliak, Peter; Kajo, Karol; Výbohová, Desanka; Mahmood, Silvia; Murín, Radovan; Tischlerová, Viera; Mojžiš, Ján; Zulli, Anthony; Péč, Martin; Adamkov, Marián; Kassayová, Monika; Bojková, Bianka; Stollárová, Nadežda; Dobrota, Dušan

doi:10.1007/s00394-015-0910-5

Cited by 59 publications

(65 citation statements)

References 32 publications

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“…Second, various compounds in this chemical group have been demonstrated to have their own anti-tumour activity. Polyphenol compounds slow the growth of various cancer cell lines and also inhibit carcinogenesis in vivo (23)(24)(25). Various plant agents, including genistein, curcumin, epigallocatechin gallate, resveratrol and proanthocyanidin, are able to potentiate the effectiveness of traditional chemotherapeutic drugs (22).…”

Section: Discussionmentioning

confidence: 99%

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Panchenko

Fedoros

Pigarev³

et al. 2018

Exp Ther Med

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Abstract. BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study examined the effect of BP-C3 (80 mg/kg, administered 18 times in total by gavage) on the development of haematological and intestinal manifestations of toxicity following 5-fluorouracil (5-FU; 150 mg/kg, administered once via intravenous injection) administration in outbred male Swiss-H Rappolovo (SHR) mice. The use of BP-C3 on therapeutic and preventative/therapeutic schedules demonstrated that it was protective against the toxic effect of 5-FU exerted on the lymphopoietic organs. Administering ВР-С3 24 h after 5-FU (therapeutic schedule) had an effect on the recovery of leukopoiesis and prevented anaemia in the mice. In the mice that received 5-FU and 5-FU with BP-C3 prior to and following administration of the chemotherapeutic agent (preventative/therapeutic schedule), mild anaemia developed by day 7. Administration of BP-C3 without 5-FU did not affect blood cell differentiation in the mice. Thus, BP-C3, depending on the administration schedule, had different effects on the haematological parameters of haematopoietic organs and peripheral blood in mice exposed to 5-FU. BP-C3 promoted intestinal crypt survival when administered on the preventative/therapeutic and therapeutic schedules, suggesting that the formulation protects the epithelium of the small intestine against damage by 5-FU.

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Section: Discussionmentioning

confidence: 99%

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Panchenko

Fedoros

Pigarev³

et al. 2018

Exp Ther Med

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“…The criteria for categorization (solidization, cell atypia, mitotic activity index and necrosis) were chosen according to the standard diagnostic method of classification. HG carcinomas were considered to be tumours with ≥2 positive criteria; LG carcinomas were tumours with ≤1 positive criterion . Serum metabolic parameters (total cholesterol, very low‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, triacylglycerols, glucose) were evaluated using an Olympus AU640 (Olympus Optical, Tokyo, Japan) automatic biochemical analyser.…”

Section: Methodsmentioning

confidence: 99%

“…The detection of selected markers of mechanism of action (mentioned below) was carried out by indirect immunohistochemical method on whole paraffin sections, utilizing commercially available rat‐specific antibodies (Santa Cruz Biotechnology, Paso Robles, CA, USA; Dako, Glostrup, Denmark; Bioss, Woburn, MA, USA; GeneTex, Irvine, CA, USA; Abcam, Cambridge, MA, USA; Boster Biological Technology, Pleasanton, CA, USA; Thermo Fisher Scientific, Rockford, IL, USA). All steps of the immunohistochemical staining were processed according to the manufacturers’ recommendations as we described previously . The concentration used for each primary antibody is as follows: caspase‐3 1:500, Bax 1:200, Bcl‐2 1:200, Ki‐67 1:50, VEGFA 1:150, VEGFR‐2 1:80, MDA 1:1000, CD24 1:200, CD44 1:200, ALDH1A1 1:500, H3K4m3 1:500, H3K9m3 1:400, H4K20m3 1:300, H4K16ac 1:200.…”

Section: Methodsmentioning

confidence: 99%

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Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Kubatka

Uramova

Kello

et al. 2017

J Cellular Molecular Medi

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It is supposed that plant functional foods, rich in phytochemicals, may potentially have preventive effects in carcinogenesis. In this study, the anticancer effects of cloves in the in vivo and in vitro mammary carcinoma model were assessed. Dried flower buds of cloves (CLOs) were used at two concentrations of 0.1% and 1% through diet during 13 weeks after the application of chemocarcinogen. After autopsy, histopathological and immunohistochemical analyses of rat mammary carcinomas were performed. Moreover, in vitro evaluation using MCF‐7 cells was carried out. Dietary administered CLO caused the dose‐dependent decrease in tumour frequency by 47.5% and 58.5% when compared to control. Analysis of carcinoma cells in animals showed bcl‐2, Ki67, VEGFA, CD24 and CD44 expression decrease and Bax, caspase‐3 and ALDH1 expression increase after high‐dose CLO administration. MDA levels were substantially decreased in rat carcinomas in both CLO groups. The evaluation of histone modifications revealed increase in lysine trimethylations and acetylations (H4K20me3, H4K16ac) in carcinomas after CLO administration. TIMP3 promoter methylation levels of CpG3, CpG4, CpG5 islands were altered in treated cancer cells. An increase in total RASSF1A promoter methylation (three CpG sites) in CLO 1 group was found. In vitro studies showed antiproliferative and pro‐apoptotic effects of CLO extract in MCF‐7 cells (analyses of cytotoxicity, Brdu, cell cycle, annexin V/PI, caspase‐7, Bcl‐2 and mitochondrial membrane potential). This study showed a significant anticancer effect of clove buds in the mammary carcinoma model in vivo and in vitro.

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“…Interestingly, the diets we have investigated have widely been reported to demonstrate substantial potential as anti-tumor agents. [20][21][22] This study used an epidemiologic survey to analyze vegetarian diet consumption in a selected population, and explore the correlation between various vegetarian dietary habits and the decreased occurrence of uterine fibroids. The macro-epidemiologic study suggested the reduced risk factors of uterine fibroids that have been described in the following text.…”

Section: Vegetarian Diet and Uterine Fibroidsmentioning

confidence: 99%

Vegetarian diet and reduced uterine fibroids risk: A case–control study in Nanjing, China

Shen

Lü

et al. 2015

J of Obstet and Gynaecol

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Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

Abstract: Our results reveal a substantial tumour-suppressive effect of F7 in the breast cancer model. We propose that the effects of phytochemicals present in this fruit extract are responsible for observed potent anti-cancer activities.

Cited by 59 publications

References 32 publications

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

Vegetarian diet and reduced uterine fibroids risk: A case–control study in Nanjing, China

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