2020
DOI: 10.1038/s41598-020-73432-2
|View full text |Cite
|
Sign up to set email alerts
|

Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms

Abstract: Natural products have been recognized as important bioactive compounds on the basis of their wide biological properties. Here we investigated the antitumor effect and molecular mechanisms of the diterpene Fruticuline A (fruti) from Salvia lachnostachys, in human cancer cell lineages and Solid Ehrlich Carcinoma in mice. Fruti reduced MCF-7 and HepG2 proliferation by the reduction of Cyclin D1 levels and decreased NF-κB gene levels in both cell types. Furthermore, fruti also induced apoptosis in HepG2 cells, red… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
1

Relationship

2
3

Authors

Journals

citations
Cited by 6 publications
(6 citation statements)
references
References 50 publications
0
6
0
Order By: Relevance
“…This demonstrates the importance, uniqueness, and pioneering nature of this study. Our findings will contribute to the ethnopharmacological indication and safety of the use of this plant since there are few studies of this species that deal with the biology of the plant and its medicinal properties [ 7 - 11 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This demonstrates the importance, uniqueness, and pioneering nature of this study. Our findings will contribute to the ethnopharmacological indication and safety of the use of this plant since there are few studies of this species that deal with the biology of the plant and its medicinal properties [ 7 - 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…Fructiculin A (a diterpene isolated or derived from S. lachnostachys ) is believed to be one of the compounds that assist in these properties, and is cited as anti-inflammatory, antihyperalgesic, antidepressant and antinociceptive [ 5 , 8 - 10 ]. Furthermore, in the literature, S. lachnostachys extract was characterized as chemopreventive and antitumor in Ehrlich models [ 7 ] and fruticulin A as antineoplastic in vitro and in vivo models [ 11 ]. Four diterpenes (fructiculine A, demethylfruticuline A, fruticuline B, and demethylfruticuline B) showed antioxidant activity [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…According to the literature, no data on maternity toxicity, reproductive performance, and embryofetal development for S. lachnostachys demonstrate this study's importance, uniqueness, and pioneering nature. Our ndings will contribute to the ethnopharmacological indication and safety of the use of this plant since there are few studies of this species that deal with the biology of the plant and its medicinal properties (7)(8)(9)(10)(11).…”
Section: Discussionmentioning
confidence: 99%
“…Fructiculin A is believed to be one of the compounds that assist in these properties, and is cited as anti-in ammatory, antihyperalgesic, antidepressant and antinociceptive (5,(8)(9)(10). Furthermore, in the literature, S. lachnostachys extract was characterized as chemopreventive and antitumor in Ehrlich models (7) and Fruticulin A as antineoplastic in preclinical in vitro and in vivo models (11). Four diterpenes (fructiculin A, dimethylfruticuline A, fruticuline B, and demethylfruticuline B) showed antioxidant activity (6).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, thymic damage occurs at late stages of cancer, specifically at day 21 after tumor inoculation, marked by the depletion of CD4 + and CD8 + cells in peripheral blood ( 34 ). All actions of immune cells in the tumor microenvironment result in cytokine expression, especially proinflammatory cytokines [e.g., interleukin-1 (IL-1), IL-4, IL-6, IL-17, and tumor necrosis factor α], the enzymes myeloperoxidase and N -acetylglucosaminidase, nitric oxide, and the anti-inflammatory cytokine IL-10 ( 17 , 18 , 35 ). IL-17 is stimulated in CD4 + cells by suppressor cells that derive from myeloid-derived suppressor cells and tumor-associated macrophages ( 35 ).…”
Section: Immune and Systemic Alterations Caused By Ehrlich Tumorsmentioning
confidence: 99%