Fruticulosin: A novel type 2 ribosome-inactivating protein from Abrus fruticulosus seeds that exhibits toxic and antileishmanial activity

Vasconcelos, Mayron Alves de; Penha, Samara Sena da; Silva, Vinícius Rodrigues Castro e; Leite, Talita Abrante; Souza, Elnatan Bezerra de; Souza, B. W. S.; Teixeira, Edson Holanda; Silva, André Luis Coelho da

doi:10.1016/j.abb.2018.09.001

Cited by 2 publications

(1 citation statement)

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“…Although only a tiny fraction of RIPs are harmful to humans when consumed, most plants used for human consumption, including rice, maize, and barley, include proteins from this family (Abbas et al 2021 ; Citores et al 2021a ). They are said to protect plants against diseases and insects (de Vasconcelos et al 2018 ; Lu et al 2022 ). Numerous studies have been conducted to investigate the potential of RIPs as antiviral and anticancer medications due to their diverse biological features (Dhanraj et al 2020 ; Cong et al 2022 ; AHMAD et al 2023 ; AMIN et al 2023 ; Ullah et al 2023a , b ).…”

Section: Introductionmentioning

confidence: 99%

In-silico analysis of ribosome inactivating protein (RIP) of the Cucurbitaceae family

Maqsood,

Sumrin,

Ali

et al. 2024

AMB Expr

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Ribosome-inactivating proteins (RIPs) are highly active N-glycosidases that depurinate both bacterial and eukaryotic rRNAs, halting protein synthesis during translation. Found in a diverse spectrum of plant species and tissues, RIPs possess antifungal, antibacterial, antiviral, and insecticidal properties linked to plant defense. In this study, we investigated the physiochemical properties of RIP peptides from the Cucurbitaceae family through bioinformatics approaches. Molecular weight, isoelectric point, aliphatic index, extinction coefficient, and secondary structures were analyzed, revealing their hydrophobic nature. The novelty of this work lies in the comprehensive examination of RIPs from the Cucurbitaceae family and their potential therapeutic applications. The study also elucidated the binding interactions of Cucurbitaceae RIPs with key biological targets, including Interleukin-6 (IL-6). Strong hydrogen bond interactions between RIPs and these targets suggest potential for innovative insilico drug design and therapeutic applications, particularly in cancer treatment. Comprehensive analysis of bond lengths using Ligpolt + software provides insights for optimizing molecular interactions, offering a valuable tool for drug design and structural biology studies.

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