FT-IR spectral analysis for a newly obtained structure analog of bexarotene

Abstract

INTRODUCTION:Retinoids are natural and synthetic compounds part of the family of polyisoprenoid lipids. These compounds are involved in several important physiological processes in the human body because of their ability to bind to different nuclear receptors. Retinoids are used in the therapy of some precancerous lesions, the treatment of acute promyelocytic leukemia (APL), T-cell lymphoma, and the prevention of malignancies in high-risk cancer groups. In this work we discuss the possibilities for analysis of the newly synthesized hydrazone of the retinoid bexarotene. AIM:The purpose of this study is to conduct FTIR spectral analysis of newly synthesized hydrazone of bexarotene. MATERIALS AND METHODS:Infrared spectra 500-4000 cm -1 were taken on a Bruker FTIR spectrometer using ATR -a plug with Smart iTR adapter. RESULTS:The infrared spectra of the newly synthesized compound were strikingly similar in the relative positions and intensities of the resulting peaks, confirming its close structural relationship with bexarotene. Despite the structural similarity, there were significant differences that point to the introduction of a substituent and the formation of a new hydrazone derivative. CONCLUSION:In order to confirm the data obtained by FTIR spectroscopy, a further reversed-phase HPLC-UV analysis of the new hydrazone derivative should be performed.