FT-IR spectroscopic study on the variations of molecular structures of some carboxyl acids induced by free electron laser

Yang, Limin; Xu, Yizhuang; Su, Yunlan; Wu, Jinguang; Chen, Jiaer; Wang, Mingkai

doi:10.1016/j.saa.2005.04.027

Cited by 39 publications

(20 citation statements)

References 6 publications

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“…Again, for the S=O band in sulfonamide, the G-SA spectra show peaks at 1,161 cm −1 , and for the amino group, peaks of 3,260 cm −1 in the microcapsules and powder mixture. For DCA powder (Figure 7B), the spectrum is in line with previously published work 41. In G-DCA-SA microcapsules (Figure 7F) and G-DCA-SA powder (Figure 7D), there was a small shift of the G peak to the right (1,603 cm −1 ).…”

Section: Resultssupporting

confidence: 89%

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Mooranian¹,

Negrulj²,

Chen-Tan³

et al. 2014

DDDT

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Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate in type 1 diabetes (T1D). In previous studies, we have shown that a gliclazide-bile acid mixture exerted a hypoglycemic effect in a rat model of T1D. We have also shown that a gliclazide-deoxycholic acid (G-DCA) mixture resulted in better G permeation in vivo, but did not produce a hypoglycemic effect. In this study, we aimed to develop a novel microencapsulated formulation of G-DCA with uniform structure, which has the potential to enhance G pharmacokinetic and pharmacodynamic effects in our rat model of T1D. We also aimed to examine the effect that DCA will have when formulated with our new G microcapsules, in terms of morphology, structure, and excipients’ compatibility. Microencapsulation was carried out using the Büchi-based microencapsulating system developed in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) at a ratio of 1:30, and G-DCA-SA (test) at a ratio of 1:3:30. Complete characterization of microcapsules was carried out. The new G-DCA-SA formulation was further optimized by the addition of DCA, exhibiting pseudoplastic-thixotropic rheological characteristics. The size of microcapsules remained similar after DCA addition, and these microcapsules showed no chemical interactions between the excipients. This was supported further by the spectral and microscopy studies, suggesting microcapsule stability. The new microencapsulated formulation has good structural properties and may be useful for the oral delivery of G in T1D.

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Section: Resultssupporting

confidence: 89%

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Mooranian¹,

Negrulj²,

Chen-Tan³

et al. 2014

DDDT

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“…No changes were seen in G-FTIR spectra and no significant changes were observed within the microcapsule formulations during the shifting process. A significant peak was noticed for the presence of an amino group at 3341.05 cm À1 in the G microcapsules (Figure 5d) (Yang et al, 2005).…”

Section: Chemical Stability Studiesmentioning

confidence: 95%

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

et al. 2015

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Context: Gliclazide (G) is a commonly prescribed drug for Type 2 diabetes (T2D). In a recent study, we found that when G was combined with a primary bile acid, and gavaged to an animal model of Type 1 diabetes (T1D), it exerted a hypoglycemic effect. We hypothesized this to be due to metabolic activation of the primary bile acid into a secondary or a tertiary bile acid, which enhanced G solubility and absorption. The tertiary bile acid, taurocholic acid (TCA), has shown strong permeation-enhancing effects in vivo. Thus, we aimed to design, characterize, and test microcapsules incorporating G and TCA in an animal model of T1D. Methods: Microcapsules were prepared using the polymer sodium alginate (SA). G-SA microcapsules (control) and G-TCA-SA microcapsules (test) were extensively examined (in-vitro) at different pH and temperatures. The microcapsules were gavaged to diabetic rats, and blood glucose and G concentrations in serum were examined. Ex-vivo studies were also performed using a muscle cell line (C2C12), and cell viability and glucose intake post-treatment were examined. Results: G-TCA-SA microcapsules showed good stability, uniformity, and thermal and chemical excipient compatibilities. TCA did not change the size or the shape of the microcapsules, but it enhanced their mechanical resistance and reduced their swelling properties. G-TCA-SA enhanced the viability of C2C12 cells over 24 hours, and exerted a hypoglycemic effect in alloxan-induced type-1 diabetic rats. Conclusions: The incorporation of TCA into G-microcapsules resulted in functionally improved microcapsules with a positive effect on cell viability and glycemic control in Type-1 diabetic animals.

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“…Variations before and after FEL irradiation were characterized using FTIR spectroscopy. Previous results indicate that some structural changes are observed after FEL irradiation via the variations of frequencies and intensities in their IR spectra for some organic molecules [7][8][9][10][11][12][13][14][15][16][17], which provide a basis for the investigation of reaction process, molecular design and synthesis of new materials. In this work, structural variations of ATP, AMP, t-RNA, D-ribose and SmCl 3 -D-ribose complex were observed in their FT-IR spectra upon the irradiation of FEL.…”

Section: Introductionmentioning

confidence: 99%

FT-IR spectroscopic study on the variations of molecular structures of some carboxyl acids induced by free electron laser

Cited by 39 publications

References 6 publications

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

Study on the variations of molecular structures of some biomolecules induced by free electron laser using FTIR spectroscopy

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