FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13

Liu, Shenxiang; Huang, Mei; Feng, Ying; Chen, Jingde; Chao, Qian; Yin, Xudong; Quan, Ming

doi:10.1016/j.yexcr.2020.111894

Cited by 52 publications

(49 citation statements)

References 26 publications

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“…Liu et al found the expression of FTO in esophageal squamous cell carcinoma (ESCC) to be higher than in adjacent normal tissues, and the corresponding survival curve showed the high expression of FTO to tend toward poor prognosis. In terms of function, FTO silencing inhibited the growth and migration of ESCC cells in CCK8 and transwell assays, whereas FTO overexpression showed the opposite results [42]. Inhibition of IPO7 by siRNA is known to lead to reduced proliferation of prostate cancer cells [43].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma

Guo

Shao

Jiang

et al. 2020

Preprint

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Background Alterations in RNA-binding proteins (RBPs) are reported in various cancer types; however, the role of RBPs in bladder urothelial cancer (BLCA) remains unknown. This study aimed to systematically examine the function and prognostic significance of RBPs in bladder cancer using bioinformatics analyses. Methods RNA sequencing and clinical data for BLCA were downloaded from The Cancer Genome Atlas (TCGA) database, and differentially expressed RBPs (DERBPs) between normal and cancer tissues were identified. Protein-protein interaction (PPI) network of DERBPs was established, and enrichment analysis and visualizations were performed. A total of 404 patients with BLCA from TCGA database were randomly divided into training and testing groups. A prognostic model was constructed using the data from training group, and validated in the testing group. Receiver operating characteristic (ROC) curve and survival analysis were performed to explore the prognostic value of the model. A nomogram was established to predict survival in bladder cancer patients. Finally, the verification of prognosis-related hub RBP survival analysis were performed. Results A total of 388 DERBPs were identified, including 219 upregulated and 169 downregulated RBPs. All RBPs were screened for prognostic model establishment and 9 RBPs (TRIM71, YTHDC1, DARS2, XPOT, ZNF106, FTO, IPO7, EFTUD2, and CTU1) were regarded as prognosis-related hub RBPs in BLCA. Further analysis revealed worse overall survival (OS) in the high-risk cohort compared to the model-based low-risk cohort. The area under the ROC curve was 0.752 in the training group and 0.701 in the testing group, which confirms the good prediction ability. A nomogram was established according to nine prognosis-related RBPs, which showed well predicting ability for BLCA. BLCA patients with high DARS2, XPOT, ZNF106, FTO, and IPO7 expression (on the contrary, low YTHDC1 and CTU1 expression) were correlated to poor overall survival. Conclusions The prognosis-related hub RBPs may be involved in oncogenesis, development, and metastasis of BLCA. Our results will be of great significance in revealing the pathogenesis of BLCA, and developing new therapeutic targets and prognostic molecular markers.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma

Guo

Shao

Jiang

et al. 2020

Preprint

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“…1b). Interestingly, FTO has been reported to be highly expressed in ESCC and other malignant tumors such as melanoma and gastric cancer, implying its distinct role in EAC [28,40,41]. In the correlation analysis, KIAA1429 was found to present the strongest correlation with YTHDF3.…”

Section: Discussionmentioning

confidence: 93%

“…Esophageal cancer is one of the most aggressive malignant tumors with two main histological subtypes, EAC and ESCC. Several studies have explored the association between m 6 A modi cations and ESCC [28,34,35];…”

Section: Discussionmentioning

confidence: 99%

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Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of esophageal adenocarcinoma

Zhou¹,

Li²,

Zou³

et al. 2020

Preprint

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BackgroundN6-methyladenosine (m6A) is an abundant modification in RNAs that affects RNA metabolism, and it is reported to be closely related to cancer occurrence and metastasis. The aim of this study was to identify novel prognostic biomarkers by using m6A RNA methylation regulators capable of improving the risk-stratification criteria of survival for esophageal adenocarcinoma patients.MethodsThe gene expression data of 16 m6A methylation regulators and its relevant clinical information were extracted from The Cancer Genome Atlas (TCGA) database. The expression pattern of these m6A methylation regulators was evaluated. Consensus clustering analysis was conducted to identify clusters of esophageal adenocarcinoma patients with different prognosis. Univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analysis were performed to construct multiple-gene risk signature. A survival analysis was carried out to determine the prognosis significance.ResultsTen m6A methylation regulators (HNRNPA2B1, HNRNPC, YTHDF1, METTL3, YTHDF2, RBM15, YTHDC1, WTAP, KIAA1429 and YTHDF3) showed significant up-regulation in tumor tissue. Consensus clustering analysis identified three clusters of esophageal adenocarcinoma patients with different overall survival. A five-gene signature, HNRNPA2B1, KIAA1429, WTAP, METTL16 and ALKBH5, was constructed to serve as a prognostic indicator for distinguish esophageal adenocarcinoma patients with different prognosis. The receiver operator characteristic (ROC) curve which indicated the area under the curve (AUC) were 0.803, demonstrated that the prognostic signature had preferable prediction efficiency.Conclusionsm6A methylation regulators exert as potential biomarkers for prognostic stratification of esophageal adenocarcinoma patients and might help clinicians make individualized therapy for this patient population.

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“…19 In detail, FTO had been found to modify multiple RNAs, such as microRNAs (miRNAs) 20 and messenger RNAs (mRNAs). 21 It was also significantly related with multiple biological functions of cancers, including cell cycle, 11 tumor growth, 12 proliferation, 22 survival, 23 migration, 24 invasion, 25 stem cell maintenance 26 and self-renewal. 27 In order to better describe the role of FTO in various cancers, we first searched the literature about FTO and multiple cancers in PubMed (https://pubmed.ncbi.nlm.nih.…”

Section: Introductionmentioning

confidence: 99%

<p>The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers</p>

Wang¹,

Chen²,

Qiang³

2020

OTT

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N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene ( FTO ), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However, the specific expression and pro- or anti-cancer role of FTO in various cancers remained controversial. In this review, through summarizing the available literature, we found that FTO single nucleotide polymorphisms (SNPs) were closely related with cancer risk. Additionally, the dysregulation of FTO was implicated in multiple biological processes, such as cancer cell apoptosis, proliferation, migration, invasion, metastasis, cell-cycle, differentiation, stem cell self-renewal and so on. These modulations mostly relied on the communications between FTO and specific signaling pathways, including PI3K/AKT , MAPK and mTOR signaling pathways. Furthermore, FTO had great potential for clinical application by serving as a prognostic biomarker.

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FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13

Cited by 52 publications

References 26 publications

Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma

Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma

Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of esophageal adenocarcinoma

<p>The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers</p>

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