Fucoidan-coated PIBCA nanoparticles containing oncocalyxone A: Activity against metastatic breast cancer cells

Cavalcanti, Iago Dillion Lima; Ximenes, Rafael Matos; Pessoa, Otília Deusdênia Loiola; Magalhães, Nereide Stela Santos; Nogueira, Mariane Cajubá de Britto Lira

doi:10.1016/j.jddst.2021.102698

Cited by 18 publications

(7 citation statements)

References 44 publications

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“…The nanoparticles were kept lyophilized at 4 °C in a hermetically sealed glass tube. The results correspond to the independent experiments performed in triplicate on different days [ 132 ].…”

Section: Methodsmentioning

confidence: 67%

“…The stability of the nanoparticles was evaluated in simulated gastric and intestinal pH biological media solutions, which were prepared according to Cavalcanti et al [ 132 ]. Initially, 250 μL of CAZ–ZNP–CH, TOB–ZNP–CH, or CAZ–TOB–ZNP–CH was added into 750 μL of gastric (pH 1.2) or intestinal (pH 6.8) solution in microtubes, and the microtubes were constantly stirred (70 rpm) at 37 °C for 2 h. At 30 min intervals, aliquots were withdrawn and evaluated for Ø, PDI, and ζ.…”

Section: Methodsmentioning

confidence: 99%

“…After 2 h, the formulation membrane was removed and inserted into another tube containing 30 mL of pH 6.8 solution. The agitation was maintained at 70 rpm at 37 °C, removing 3-mL aliquots after 1, 2, 3, 4, 5, 6, and 24 h and replacing the aliquots with the same volume of pH 6.8 solution, as performed by Cavalcanti et al [ 132 ].…”

Section: Methodsmentioning

confidence: 99%

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Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and Klebsiella pneumoniae

Campos,

Neto,

Scavuzzi

et al. 2024

Pharmaceuticals

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This study aimed to co-encapsulate ceftazidime and tobramycin in zein nanoparticles coated with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity against antibiotic-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Zein nanoparticles, synthesized using the nanoprecipitation method, were characterized by their particle size (Ø), polydispersity index (PDI), zeta potential (ζ), pH, and encapsulation efficiency (%EE). The chitosan coating provided stability, and physicochemical analyses revealed chemical interactions, efficient drug encapsulation, and thermal stability. The release kinetics demonstrated controlled release in simulated gastric and intestinal pH. The antibacterial activity, assessed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), indicated effectiveness against both pathogens. Antibiofilm assays, conducted using the crystal violet method, demonstrated the inhibition and eradication of biofilms. The chitosan-coated zein nanoparticles with CAZ and/or TOB exhibited Ø (315–335 nm), PDI (<0.2), ζ (+40 to +50 mV), pH (5), and %EE (>55%). Notably, the co-encapsulation formulation (CAZ–TOB–ZNP–CH) showed enhanced antibacterial and antibiofilm activities compared to the individual formulations. These findings suggest that the developed nanoparticles present a promising alternative for treating respiratory and intestinal infections caused by antibiotic-resistant and biofilm-producing P. aeruginosa and K. pneumoniae.

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Section: Methodsmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

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Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and Klebsiella pneumoniae

Campos,

Neto,

Scavuzzi

et al. 2024

Pharmaceuticals

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“…Cavalcanti et al developed fucoidan-coated poly(isobutyl cyanoacrylate) nanoparticles loaded with oncocalyxone A for the treatment of metastatic breast cancer [190]. The produced nanoparticles had an average size of 305 ± 6.49 nm and encapsulation efficiency of 100%.…”

Section: Fucoidan Nanoparticles For Cancer Therapymentioning

confidence: 99%

Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review

Zahariev,

Katsarov,

Lukova

et al. 2023

Polymers

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Fucoidan belongs to the family of marine sulfated, L-fucose-rich polysaccharides found in the cell wall matrix of various brown algae species. In the last few years, sulfated polysaccharides have attracted the attention of researchers due to their broad biological activities such as anticoagulant, antithrombotic, antidiabetic, immunomodulatory, anticancer and antiproliferative effects. Recently the application of fucoidan in the field of pharmaceutical technology has been widely investigated. Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity, used for targeted delivery of chemotherapeutics in oncology. Furthermore, the presence of sulfate residues with negative charge in its structure enables fucoidan to form ionic complexes with oppositely charged molecules, providing relatively easy structure-forming properties in combination with other polymers. The aim of the present study was to overview essential fucoidan characteristics, related to its application in the development of pharmaceutical formulations as a single drug carrier or in combinations with other polymers. Special focus was placed on micro- and nanosized drug delivery systems with polysaccharides and their application in the field of oncology.

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“…The diverse fucoidan-based carriers have been developed during recent years as nanoparticles for different purposes, such as for the releasing of the antitumor drug curcumin [ 90 , 91 ], the delivery of the anticancer drug doxorubicin [ 112 ], the encapsulation of the anticancer drug docetaxel (DTX) [ 113 ], for loading anticancer methotrexate (MTX) [ 114 ], for the delivery of antimicrobial and anti-inflammatory berberine [ 185 , 186 , 187 ], for the delivery of antitumor, anti-inflammatory, antioxidant, and hypoglycemic Oncocalyxone A [ 188 ], for releasing antibiotic gentamicin [ 189 ], for the carrying of basic fibroblast growth factor (bFGF) [ 190 ] and stromal cell-derived factor [ 191 ] as microparticles for the delivery lipoic acid, as hydrogels for releasing fibroblast growth factor-2 in vitro and in vivo [ 192 ], as nanoparticles functionalized with antibody-ErbB-2 for reducing tumor growth of lung [ 193 ], as 3D scaffolds for delivery vascular endothelial growth factor [ 115 , 116 ], and as polymeric micelles for loading the antitumor paclitaxel and curcumin [ 117 ] ( Figure 2 ).…”

Section: Medicinementioning

confidence: 99%

Bioactive Carbohydrate Polymers—Between Myth and Reality

et al. 2021

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Polysaccharides are complex macromolecules long regarded as energetic storage resources or as components of plant and fungal cell walls. They have also been described as plant mucilages or microbial exopolysaccharides. The development of glycosciences has led to a partial and difficult deciphering of their other biological functions in living organisms. The objectives of glycobiochemistry and glycobiology are currently to correlate some structural features of polysaccharides with some biological responses in the producing organisms or in another one. In this context, the literature focusing on bioactive polysaccharides has increased exponentially during the last two decades, being sometimes very optimistic for some new applications of bioactive polysaccharides, notably in the medical field. Therefore, this review aims to examine bioactive polysaccharide, taking a critical look of the different biological activities reported by authors and the reality of the market. It focuses also on the chemical, biochemical, enzymatic, and physical modifications of these biopolymers to optimize their potential as bioactive agents.

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Fucoidan-coated PIBCA nanoparticles containing oncocalyxone A: Activity against metastatic breast cancer cells

Cited by 18 publications

References 44 publications

Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and Klebsiella pneumoniae

Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and Klebsiella pneumoniae

Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review

Bioactive Carbohydrate Polymers—Between Myth and Reality

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