Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells

Yang, Mingshi; Ma, Chao; Sun, Jia; Shao, Qianqian; Gao, Wenjuan; Zhang, Yan; Li, Zewu; Xie, Qi; Dong, Zhaogang; Qu, Xun

doi:10.1016/j.intimp.2008.08.007

Cited by 70 publications

(47 citation statements)

References 33 publications

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“…T cells, and demonstrated that PA-MSHA treated Mo-DCs induced Th cells to Th1 cells with high proliferative capacity. These results are quite similar to the Mo-DCs treated with anti-tumor or antiinfection pharmacological agents to induce Th1 [10]. ; B:PA-MSHA group 7.2 9 10 7 ml -1…”

Section: Discussionsupporting

confidence: 73%

“…In addition, the direction of T cells polarization determined the prognosis of many infectious diseases and cancers. In cancer patients with high expression of the Th1 cells had a prolonged disease-free survival [10], while with high expression of the Th2 cells, the patients had a poor progressive [11]. It was reported that Th1 immunity was compromised in infections, while enhancing Th1 responses improved the anti-inflammatory effect [12,13].…”

Section: Introductionmentioning

confidence: 99%

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The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Zhang

Wang

Li³

et al. 2013

Indian J Microbiol

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Pseudomonas aeruginosa mannose sensitive hamemagglutination strain (PA-MSHA) is a kind of peritrichous P. aeruginosa strain with MSHA fimbriae and has been shown to activate kinds of immunocytes. Dendritic cells (DCs) are specialized antigen-presenting cells required for the stimulating and priming CD4? T cells toward the T helper cell type 1 (Th1), Th2 and other different phenotypes. PA-MSHA effecting on Th1 remains an important missing link. Here we demonstrated that PA-MSHA augmented monocytes derived-dendritic cells (Mo-DCs) expression of HLA-DR, co-stimulatory and adhesion molecules, and induced Th1-promoting interleukin-12 and tumor necrosis factor a secretion, in addition, PA-MSHA treated MoDCs displayed lesser endocytic capacity. Furthermore, in mixed lymphocyte reactions, allostimulatory capacity of Mo-DCs was enhanced by PA-MSHA, CD4? T cells stimulated by PA-MSHA -activated Mo-DCs showed a Th1-polarized cytokine production, increasing secretion of IFN-c and decreasing secretion of IL-10 and IL-4. Our findings identified PA-MSHA as an important exogenous factor that induced DCs maturation toward a Th1-promoting phenotype.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Zhang

Wang

Li³

et al. 2013

Indian J Microbiol

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“…Moreover, fucoidan, a sulfated polysaccharide, has been well defined as a maturation-inducing agent on human monocyte-derived DCs (MDDCs), peripheral blood DCs (PBDCs) and mouse bone marrow-derived DCs (BMDCs) [20,21,22]. However sulfated polysaccharide-mediated immune responses in vivo , especially DC maturation and T cell activation, have not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Ascophyllan Purified from Ascophyllum nodosum Induces Th1 and Tc1 Immune Responses by Promoting Dendritic Cell Maturation

Zhang

Jiang

et al. 2014

Marine Drugs

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Marine-derived sulfated polysaccharides have been shown to possess certain anti-virus, anti-tumor, anti-inflammatory and anti-coagulant activities. However, the in vivo immunomodulatory effects of marine-derived pure compounds have been less well characterized. In this study, we investigated the effect of ascophyllan, a sulfated polysaccharide purified from Ascophyllum nodosum, on the maturation of mouse dendritic cells (DCs) in vitro and in vivo. Ascophyllan induced up-regulation of co-stimulatory molecules and production of pro-inflammatory cytokines in bone marrow-derived DCs (BMDCs). Moreover, in vivo administration of ascophyllan promotes up-regulation of CD40, CD80, CD86, MHC class I and MHC class II and production of IL-6, IL-12 and TNF-α in spleen cDCs. Interestingly, ascophyllan induced a higher degree of co-stimulatory molecule up-regulation and pro-inflammatory cytokine production than fucoidan, a marine-derived polysaccharide with well-defined effect for promoting DC maturation. Ascophyllan also promoted the generation of IFN-γ-producing Th1 and Tc1 cells in the presence of DCs in an IL-12-dependent manner. Finally, myeloid differentiation primary response 88 (MyD88) signaling pathway was essential for DC maturation induced by ascophyllan. Taken together, these results demonstrate that ascophyllan induces DC maturation, and consequently enhances Th1 and Tc1 responses in vivo. This knowledge could facilitate the development of novel therapeutic strategies to combat infectious diseases and cancer.

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“…11) It has been reported that fucoidan had various pharmacological properties such as an anti-coagulant, 12) anti-tumor, 13) anti-inflammatory, 14) and anti-oxidant, 15) and promoted the immune function. 16) Fucoidan also protected tissues from various types of injury by increasing the hepatic growth factor (HGF). 17) Fucoidan has recently been reported to reduce liver fibrogenesis by protecting from hepatic cell death and inducing HSC death, 18) as well as showing anti-oxidative properties against CCl 4 -induced acute liver injury.…”

mentioning

confidence: 99%

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

Hong

Jung

Lee

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells

Cited by 70 publications

References 33 publications

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Ascophyllan Purified from Ascophyllum nodosum Induces Th1 and Tc1 Immune Responses by Promoting Dendritic Cell Maturation

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

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