Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor

Kurihara, Hideyuki; Konno, Remi; Takahashi, Kyoko

doi:10.1080/09168451.2015.1062716

Cited by 19 publications

(10 citation statements)

References 21 publications

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“…Fucophlorethol C isolated from Dactylosiphon bullosus (formerly known as Colpomenia bullosa) has a lipoxygenase inhibition activity, in soybean, with comparable power to the nordihydroguaiaretic acid (obtained from Zygophyllaceae plants), which is the most well-known inhibitor. This inhibitor is expected to suppress various lipoxygenase-related diseases, such as psoriasis, asthma, rhinitis, and arthritis [244].…”

Section: Phlorotanninsmentioning

confidence: 99%

Seaweed Phenolics: From Extraction to Applications

et al. 2020

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Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyphenol class is the phlorotannins, which are specifically synthesized by brown seaweeds, but there are other polyphenolic compounds, such as bromophenols, flavonoids, phenolic terpenoids, and mycosporine-like amino acids. The compounds already discovered and characterized demonstrate a full range of bioactivities and potential future applications in various industrial sectors. This review focuses on the extraction, purification, and future applications of seaweed phenolic compounds based on the bioactive properties described in the literature. It also intends to provide a comprehensive insight into the phenolic compounds in seaweed.

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Section: Phlorotanninsmentioning

confidence: 99%

Seaweed Phenolics: From Extraction to Applications

et al. 2020

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“…This insightful paper outlines the approaches necessary for using VCD in the determination of absolute conguration. 537 The rst asymmetric synthesis of (À)-dolastatrienol (14-hydroxydolasta-1(15),7,9-triene) 538 was reported 539 along with a concise synthesis of dictyodendrins A and F. 540 Additionally, there were many papers and reviews dealing with the biological properties of brown algal polyphenolics [541][542][543][544][545][546][547][548][549][550][551][552][553][554][555][556][557] and carotenoids. 15,[558][559][560][561][562] 6 Red algae…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…TLC analysis and NMR data showed that compound 4 is authentic fucophlorethol C, which was isolated previously from the same alga. 12…”

Section: Resultsmentioning

confidence: 99%

Phlorotannins Derived From the Brown Alga Colpomenia bullosa as Tyrosinase Inhibitors

Kurihara

Kujira

2021

Natural Product Communications

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Tyrosinase catalyzes hydroxylation of L-tyrosine and dehydrogenation of L-DOPA in the melanin biosynthesis pathway. Tyrosinase inhibitors have potential use as cosmetic whitening agents and for preventing seafood deterioration. In this report, tyrosinase inhibitors extracted from brown alga Colpomenia bullosa (Scytosiphonaceae, Scytosiphonales) were investigated. Inhibitory principles were isolated from the extract and identified as phlorotannins, phloroglucinol (1), diphlorethol (2), triphlorethol C (3), which have not been isolated in a free form previously, and fucophlorethol C (4). Compounds 3 and 4 have not been reported previously as tyrosinase inhibitors. Triphlorethol C (3) was the most potent tyrosinase inhibitor among the phlorotannins isolated, whereas isomeric fucophlorethol C (4) displayed the weakest inhibitory activity. The results suggest that molecular structures of phlorotannins strongly affect their tyrosinase inhibitory activity.

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Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor

Cited by 19 publications

References 21 publications

Seaweed Phenolics: From Extraction to Applications

Seaweed Phenolics: From Extraction to Applications

Marine natural products

Phlorotannins Derived From the Brown Alga Colpomenia bullosa as Tyrosinase Inhibitors

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