Fuel Cycle to Nowhere

Stewart, Richard Burleson; Stewart, Jane

doi:10.2307/j.ctv16756ck

Cited by 22 publications

(2 citation statements)

References 26 publications

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“…The SLC14 family are facilitative transporters, allowing urea movement down its concentration gradient. Multiple splice variants of these transporters have been identified; for UT-A transporters, in particular, there is evidence for cell-specific expression of these variants with functional impact [589]. Topographical modelling suggests that the majority of the variants of SLC14 transporters have 10 TM do-mains, with a glycosylated extracellular loop at TM5/6, and intracellular C-and N-termini.…”

Section: Slc14 Family Of Facilitative Urea Transportersmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

Alexander

Kelly

Mathie

et al. 2019

British J Pharmacology

235

212

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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (http://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14753. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: Slc14 Family Of Facilitative Urea Transportersmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

Alexander

Kelly

Mathie

et al. 2019

British J Pharmacology

235

212

View full text Add to dashboard Cite

show abstract

“…The SLC14 family are facilitative transporters, allowing urea movement down its concentration gradient. Multiple splice variants of these transporters have been identified; for UT-A transporters, in particular, there is evidence for cell-specific expression of these variants with functional impact [11,679]. Topographical modelling suggests that the majority of the variants of SLC14 transporters have 10 TM domains, with a glycosylated extracellular loop at TM5/6, and intracellular C-and N-termini.…”

Section: Slc14 Family Of Facilitative Urea Transportersmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

Alexander,

Fabbro,

Kelly

et al. 2023

British J Pharmacology

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The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16182. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Risk Management and Challenges of Managing in the Public Sector

Posner

Stanton

2014

Managing Risk and Performance

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Fuel Cycle to Nowhere

Cited by 22 publications

References 26 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

Risk Management and Challenges of Managing in the Public Sector

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