Full ablative versus fractional ablative laser therapy for Dowling–Degos disease

Abstract

Dowling–Degos disease (DDD) is a rare autosomal‐dominant genodermatosis with limited treatment possibilities. Although the efficacy of ablative laser therapy has been reported, we sought to examine the efficacy of fractional versus full ablative laser therapy in a female patient with DDD in a split‐side report. We treated the lesions on the right side of the patient's upper abdomen with an ablative fractional CO2 laser and the lesions on the left side of the upper abdomen with a full ablative Er:YAG laser (erbium‐doped yttrium aluminium garnet laser) three times at monthly intervals. After three laser sessions, the lesions treated with the Er:YAG laser showed a complete response, whereas the fractional CO2 laser treatment was less effective. After the three treatments were performed, the right side of the patient's upper abdomen and portions of her lower abdomen and chest were also treated with the Er:YAG laser in full ablation mode with the same settings. After 1 year of follow up, there was no recurrence observed. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

Galli–Galli Disease: A Comprehensive Literature Review

“…This event was not observed in this case, as the remaining skin was unaffected [23,58]. Only a single case could not be categorized as typical, atypical, or segmental due to insufficient data [31].…”

“…In recent years, three additional cases of GGD with POGLUT1 mutation were identified: one with a c.1013delTinsAAC [30], one with c.652 > T [4], and one with c.798-2A > C [31].…”

“…The disease involves individuals between the second and ninth decades of life, reaching its peak in the third and fifth decade [5,7,45]. The majority of patients were Caucasians (52/63) [1][2][3][4]6,18,19,[21][22][23][24]31,42,43,[45][46][47][48][49][50][51][52], followed by Indians (6) [9,44], Asians (5) [53], Africans (1) [34], Arabians (1) [20], Asian-Americans (1) [8], Japanese (1) [30], and Latin Americans (1) [54]. In one case the race is unspecified [5].…”

“…Characteristic features consist of filiform, digitated hyperplasia of the epidermal ridges, basal hyperpigmentation of the tips of rete ridges, multiple foci of acantholysis in the upper spinous and/or granular layer, and narrowing of the suprapapillary epidermis with widened granular cell layer [5,7,8,49,50]. Some dyskeratotic keratinocytes may also be seen [3,4,8,30,31,43,45,50,51,55,56]. It should be noted that these findings are not consistently present and may vary depending on the stage of the disease.…”

Dowling‐Degos disease: a review

“…It was found that the CO 2 laser treatment was less effective than the Er:YAG modality. There was complete response with the areas treated with Er:YAG while there were persistent lesions in the areas treated with CO 2 laser 63 …”