Full Recovery from a Potentially Lethal Dose of Mercuric Chloride

Beasley, D. M. G.; Schep, Leo J.; Slaughter, Robin J; Temple, Wayne A.; Michel, Jonathan

doi:10.1007/s13181-013-0311-1

Cited by 27 publications

(18 citation statements)

References 25 publications

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“…In fact, anthropogenic activity (i.e., artisanal gold mining) has exposed humans to chronic intoxication by inorganic mercury, which leads to deleterious health effects ( Doering et al, 2016 ). The literature on intoxication and inorganic mercury exposure in humans consists of reports of clinical cases ( Triunfante et al, 2009 ; Benz et al, 2011 ; Beasley et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Teixeira

Oliveira

Leão

et al. 2018

Front. Mol. Neurosci.

106

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Mercury is a toxic metal that can be found in the environment in three different forms – elemental, organic and inorganic. Inorganic mercury has a lower liposolubility, which results in a lower organism absorption and reduced passage through the blood–brain barrier. For this reason, exposure models that use inorganic mercury in rats in order to evaluate its effects on the central nervous system are rare, especially in adult subjects. This study investigated if a chronic exposure to low doses of mercury chloride (HgCl2), an inorganic form of mercury, is capable of promoting motor alterations and neurodegenerative in the motor cortex of adult rats. Forty animals were exposed to a dose of 0.375 mg/kg/day, for 45 days. They were then submitted to motor evaluation and euthanized to collect the motor cortex. Measurement of mercury deposited in the brain parenchyma, evaluation of oxidative balance, quantification of cellular cytotoxicity and apoptosis and density of mature neurons and astrocytes of the motor cortex were performed. It was observed that chronic exposure to inorganic mercury caused a decrease in balance and fine motor coordination, formation of mercury deposits and oxidative stress verified by the increase of lipoperoxidation and nitrite concentration and a decrease of the total antioxidant capacity. In addition, we found that this model of exposure to inorganic mercury caused cell death by cytotoxicity and induction of apoptosis with a decreased number of neurons and astrocytes in the motor cortex. Our results provide evidence that exposure to inorganic mercury in low doses, even in spite of its poor ability to cross biological barriers, is still capable of inducing motor deficits, cell death by cytotoxicity and apoptosis, and oxidative stress in the motor cortex of adult rats.

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Section: Introductionmentioning

confidence: 99%

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Teixeira

Oliveira

Leão

et al. 2018

Front. Mol. Neurosci.

106

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“…The lethal dose of mercuric chloride is 1 -4g per an adult. However fatalities have been reported with doses as small as 0.5g (8). A search of literature shows eight cases of intentional mercury chloride poisoning.…”

Section: Discussionmentioning

confidence: 99%

Complete recovery following “Veeram” (Mercury II chloride) poisoning: A case report

2019

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Veeram is a local term used in Nothern Sri Lanka, for impure mercury (II) chloride. (HgCl 2). We describe a case with acute, suicidal, mercury (II) chloride poisoning, who presented with confusion, acidosis and renal shut down. He was managed with mercury chelation using penicillamine, and acutre renal failure with hemodialysis. He made a complete renal recovery on discharge, and on follow up he did not have any neurological symptoms, and have made a complete clinical recovery. A discussion on the acute mercury poisoning follows.

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“…Gastric lavage should be performed within the first 6 hours, controlling lavage efficacy through serial abdominal X-rays. Although controversial, activated charcoal should be used, because unlike heavy metals, mercury binds charcoal tightly [1,13]. After Hg° ingestion a superior digestive endoscopy can be performed in order to find any digestive lesions, which may increase mercury absorption [5].…”

Section: Discussionmentioning

confidence: 99%

Acute mercury poisoning from occult ritual use

Tincu

Cobilinschi

Ghiorghiu

et al. 2016

Rom J Anaesth Int Care

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Mercury exposure is a serious environmental issue that concerns people worldwide. Industrial emissions containing mercury, some pharmaceutical and cosmetic products represent exposure sources. In Romania, as in many other countries, a supplementary cause for mercury exposure is represented by various occult rituals where liquids containing mercury are supposed to be ingested. We present the case of a 28 year old female who was admitted to the hospital for oral paresthesia, nausea, vertigo and sialorrhoea, after ingesting 100 ml diluted liquid mercury during an occult ritual. After the gastrointestinal decontamination, including gastric lavage, activated charcoal and cathartics, the outcome was favourable and 48 hours after admission the patient was discharged. This case report emphasizes the importance of an early digestive decontamination in mercury poisoning and the danger of mercury ingestion during various occult rituals.

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Full Recovery from a Potentially Lethal Dose of Mercuric Chloride

Cited by 27 publications

References 25 publications

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Complete recovery following “Veeram” (Mercury II chloride) poisoning: A case report

Acute mercury poisoning from occult ritual use

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