Full-view 3D imaging system for functional and anatomical screening of the breast

Oraevsky, Alexander A.; Su, Richard; Nguyen, Ha Q.; Moore, James B.; Lou, Yang; Bhadra, Sayantan; Forte, Luca Antonio; Anastasio, Mark A.; Yang, Wei Tse

doi:10.1117/12.2318802

Cited by 35 publications

(83 citation statements)

References 25 publications

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“…Several PA breast imaging systems have been developed over the last years, all designed differently and for varying applications [5][6][7][8][18][19][20][21][22][23][24]. Carefully controlled laboratory experiments with these systems can identify the most efficient and robust measurement protocols that will provide success in the clinics [25].…”

Section: Preparing a Photoacoustic System For Clinical Studiesmentioning

confidence: 99%

Semi-anthropomorphic photoacoustic breast phantom

Dantuma¹,

Dommelen²,

Manohar³

2019

Biomed. Opt. Express

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Imaging parameters of photoacoustic breast imaging systems such as the spatial resolution and imaging depth are often characterized with phantoms. These objects usually contain simple structures in homogeneous media such as absorbing wires or spherical objects in scattering gels. While these kinds of basic phantoms are uncluttered and useful, they do not challenge the system as much as a breast does, and can thereby overestimate the system's performance. The female breast is a complex collection of tissue types, and the acoustic and optical attenuation of these tissues limit the imaging depth, the resolution and the ability to extract quantitative information. For testing and challenging photoacoustic breast imaging systems to the full extent before moving to in vivo studies, a complex breast phantom which simulates the breast's most prevalent tissues is required. In this work we present the first three dimensional multi-layered semi-anthropomorphic photoacoustic breast phantom. The phantom aims to simulate skin, fat, fibroglandular tissue and blood vessels. The latter three are made from custom polyvinyl chloride plastisol (PVCP) formulations and are appropriately doped with additives to obtain tissue realistic acoustic and optical properties. Two tumors are embedded, which are modeled as clusters of small blood vessels. The PVCP materials are surrounded by a silicon layer mimicking the skin. The tissue mimicking materials were cast into the shapes and sizes expected in the breast using 3D-printed moulds developed from a magnetic resonance imaging segmented numerical breast model. The various structures and layers were assembled to obtain a realistic breast morphology. We demonstrate the phantom's appearance in both ultrasound imaging as photoacoustic tomography and make a comparison with a photoacoustic image of a real breast. A good correspondence is observed, which confirms the phantom's usefulness.

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Section: Preparing a Photoacoustic System For Clinical Studiesmentioning

confidence: 99%

Semi-anthropomorphic photoacoustic breast phantom

Dantuma¹,

Dommelen²,

Manohar³

2019

Biomed. Opt. Express

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“…Current results indicate that using multiple light illumination angles, along with optimizing imaging geometry can improve light penetration. 34,51 In addition to that, engineering PA-based contrast agents could be another solution to facilitate deep tissue imaging. [85][86][87] Second, although multispectral PA imaging enables the functional quantification of breast tissue, the complexity of light absorption and scattering in tissue make the quantification inaccurate.…”

Section: Discussionmentioning

confidence: 99%

“…So far, US imaging could only be achieved using a secondary transducer array, which needs additional image co-registration. 47 Another hemispherical system implemented by Oraevsky et al 51 features an arc-shaped transducer that is rotated around the breast. This system, called the laser optoacoustic imaging system assembly (LOUISA-3D), consists of two subsystems-the PA subsystem and the US subsystem.…”

Section: Hemispherical Imaging Systemsmentioning

confidence: 99%

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Photoacoustic imaging of breast cancer: a mini review of system design and image features

2019

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Breast cancer is one of the leading causes for cancer related deaths in women, and early detection is extremely important to improve survival rates. Currently, x-ray mammogram is the only modality for mass screening of asymptomatic women. However, it has decreased sensitivity in radiographically dense breasts, which is also associated with a higher risk for breast cancer. Photoacoustic (PA) imaging is an emerging modality that enables deep tissue imaging of optical contrast at ultrasonically defined spatial resolution, which is much higher than that can be achieved in purely optical imaging modalities. Because of high optical absorption from hemoglobin molecules, PA imaging can map out hemo distribution and dynamics in breast tissue and identify malignant lesions based on tumor associated angiogenesis and hypoxia. We review various PA breast imaging systems proposed over the past few years and summarize the PA features of breast cancer identified in these systems.

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“…The application of photoacoustic (PA) imaging in breast cancer screening and diagnosis is still in its infancy, but more and more applications are being found. [1][2][3] Blood vessels inside the breast can be visualized, but multiwavelength PA imaging has shown to be able to provide quantitative oxygen saturation estimations. 4 Several devices are being developed and/or optimized for clinical trials at the moment.…”

Section: Introductionmentioning

confidence: 99%

A 3D semi-anthropomorphic photoacoustic breast phantom

Dantuma

Dommelen

Manohar

2019

Photons Plus Ultrasound: Imaging and Sensing 2019

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Photoacoustic tomographic breast imaging systems progressively move into the clinics for in-vivo studies. Next to tumor detection, studies also focus on extracting information about the tumor by performing multi-wavelength photoacoustics for quantitative oxygen saturation estimations. Until now, it has been difficult to compare the results from different systems due to the wide variability in system characteristics and image reconstruction algorithms. In order to do inter-system comparisons in photoacoustic breast imaging, and to validate oxygen saturation estimations, a standardized but realistic measurement object is required. In this study, we present the first 3D semi-anthropomorphic photoacoustic breast phantom and demonstrate its features both in ultrasound imaging as in photoacoustic tomography.

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Full-view 3D imaging system for functional and anatomical screening of the breast

Cited by 35 publications

References 25 publications

Semi-anthropomorphic photoacoustic breast phantom

Semi-anthropomorphic photoacoustic breast phantom

Photoacoustic imaging of breast cancer: a mini review of system design and image features

A 3D semi-anthropomorphic photoacoustic breast phantom

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