Fully Automated Quantification of Regional Cerebral Blood Flow With Three-dimensional Stereotaxic Region of Interest Template: Validation Using Magnetic Resonance Imaging. Technical Note.

Abstract

The previously reported three-dimensional stereotaxic region of interest (ROI) template (3DSRT-t) for the analysis of anatomically standardized technetium-99m-L,L-ethyl cysteinate dimer ( 99m Tc-ECD) single photon emission computed tomography (SPECT) images was modified for use in a fully automated regional cerebral blood flow (rCBF) quantification software, 3DSRT, incorporating an anatomical standardization engine transplanted from statistical parametric mapping 99 and ROIs for quantification based on 3DSRT-t. Three-dimensional T 2 -weighted magnetic resonance images of 10 patients with localized infarcted areas were compared with the ROI contour of 3DSRT, and the positions of the central sulcus in the primary sensorimotor area were also estimated. All positions of the 20 lesions were in strict accordance with the ROI delineation of 3DSRT. The central sulcus was identified on at least one side of 210 paired ROIs and in the middle of 192 (91.4%) of these 210 paired ROIs among the 273 paired ROIs of the primary sensorimotor area. The central sulcus was recognized in the middle of more than 71.4% of the ROIs in which the central sulcus was identifiable in the respective 28 slices of the primary sensorimotor area. Fully automated accurate ROI delineation on anatomically standardized images is possible with 3DSRT, which enables objective quantification of rCBF and vascular reserve in only a few minutes using 99m Tc-ECD SPECT images obtained by the RVR method.

Utility of the Bender Gestalt Test for Differentiation of Dementia with Lewy Bodies from Alzheimer’s Disease in Patients Showing Mild to Moderate Dementia

“…The degrees of brain atrophy and cerebrovascular disease were evaluated with T 1 -and T 2 -weighted imagings of brain MRI, respectively. In brain SPECT, regional cerebral blood flow was quantitatively measured by the 3-dimensional stereotaxic region of interest template (3DSRT) [37] .…”

Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia

“…The rCBF was quantified using the fully automated rCBF quantification software program 3DSRT [8,9] . There are 318 ROIs in each hemisphere in 3DSRT, that is, 636 ROIs in total.…”

“…There are 318 ROIs in each hemisphere in 3DSRT, that is, 636 ROIs in total. These 636 ROIs are categorized into 12 segments in the 3DSRT template: the callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampal, and cerebellar segments [9] . In this study, the results are expressed as the mean 8 SD of CBF in these segments.…”

“…However, the reproducibility and objectivity of the results are controversial because small ROIs were placed manually on selected slices of the SPECT images of the patient. Takeuchi et al [8][9][10] developed a fully automated rCBF quantification software program, 3DSRT, that allows objective assessment of rCBF by selecting identical ROIs on anatomically standardized SPECT images.…”

Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography

“…23 The 3DSRT template uses the algorithm of statistical parametric mapping (SPM99) software (Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK) to standardize anatomical coordinates based on those of the Montreal Neurological Institute (MNI). The final matched spatial resolution of pCASL and IMP SPECT images was 2.0 © 2.0 © 2.0 mm 3 (FOV, 158 © 190 mm; re-gridding matrix, 79 © 95).…”