Fulminant hepatic failure in poisoning due to ingestion of T 61, a veterinary euthanasia drug

Dimethylformamide metabolism following self-harm using a veterinary euthanasia product

“…3 Delayed hepatotoxicity has been observed in suicide cases that recovered from the initial manifestations and can be attributed to the solvent, DMF, or its metabolites. 3,4 From 1979, 15 publications have reported a total of 32 cases of T-61 poisoning. As in our cases, the patients were mainly veterinarians, veterinary assistants, or members of their families.…”

“…One patient died on day 9 from hepatic failure; he had ingested 50 mL of T-61 and did not receive NAC. 4 Another patient recovered from severe hepatic failure after having received reduced glutathione (GSH) from day 5 to 27. 5 Four patients were treated with NAC for a duration ranging from 2 to 7 days.…”

Intentional misuse of veterinary medications in human suicide

“…Eight cases of death following self-administration of mebezonium and embutramide have been reported (Bertol et al, 1983;Smith & Lewis, 1989;Nicolas et al, 1990;Kintz et al, 2002;Morini et al, 2012;Musshoff et al, 2013). The most common proprietary combination used in these cases was T-61, with a minority of cases involving Tanax.…”

“…Veterinary medications used in completed suicideBertol et al, 1983;Smith & Lewis, 1989;Nicolas et al, 1990;Kintz et al, 2002;Morini et al, 2012; …”