Fumaric acid incorporated Ag/agar-agar hybrid hydrogel: A multifunctional avenue to tackle wound healing

Basha, Syed Ilias; Ghosh, Somnath; Vinothkumar, K.; Ramesh, B M; Kumari, Puja; Mohan, Kritika; Sukumar, E.

doi:10.1016/j.msec.2020.110743

Cited by 77 publications

(31 citation statements)

References 72 publications

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“…Most of the absorption peaks of PPO/PEO‐C have slight shifts in the hybrid nanocomposite hydrogel due to the interface interaction between Ag NPs and matrix. Our findings are in agreement with the previous work obtained from an AA‐Ag‐FA hydrogel, a multifunctional approach to tackle wound healing 54 . Similar explanations are obtained during the synthesis of hydrogel using an optimized crosslinking konjac glucomannan and chitosan 55…”

Section: Resultssupporting

confidence: 92%

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Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

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Section: Resultssupporting

confidence: 92%

“…Our findings are in agreement with the previous work obtained from an AA-Ag-FA hydrogel, a multifunctional approach to tackle wound healing. 54 Similar explanations are obtained during the synthesis of hydrogel using an optimized crosslinking konjac glucomannan and chitosan. 55…”

Section: Ftir Studymentioning

confidence: 53%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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“…In general, DPPH clearance efficiency is positively correlated with antioxidant capacity ( p < 0.05). According to previous studies, Ag loadings of < 0.02 wt% can result in DPPH clearance efficiencies of > 20% [60] . Herein, clearance efficiencies of > 60% were achieved for membranes with 1 wt% AgNPs ( Fig.…”

Section: Resultsmentioning

confidence: 81%

Electrospun antibacterial poly(vinyl alcohol)/Ag nanoparticles membrane grafted with 3,3′,4,4′-benzophenone tetracarboxylic acid for efficient air filtration

Zhang

Xie

et al. 2020

Applied Surface Science

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“…Traditional dressings and sealants often require the use of antibiotics to prevent microbial infection [ 40 ]. Researchers have demonstrated that the incorporation of nanoparticles can endow hydrogels with antipathogenic properties [ 34 , 39 , 44 , 56 , 73 ], as well as add angiogenic, or adhesive properties [ 27 , 29 , 35 , 40 , 74 , 75 ], thus improving their use for wound healing [ 57 , 76 , 77 ].…”

Section: Wound Healingmentioning

confidence: 99%

Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021

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Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications including tissue engineering, drug delivery, wound healing, bioprinting, and biowearable devices.

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Fumaric acid incorporated Ag/agar-agar hybrid hydrogel: A multifunctional avenue to tackle wound healing

Cited by 77 publications

References 72 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Electrospun antibacterial poly(vinyl alcohol)/Ag nanoparticles membrane grafted with 3,3′,4,4′-benzophenone tetracarboxylic acid for efficient air filtration

Multifunctional Hydrogel Nanocomposites for Biomedical Applications

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