Fumaric acid therapy in psoriasis: Results and side effects of 2 years of treatment

Kolbach, Dinanda N; Nieboer, C.

doi:10.1016/s0190-9622(08)80228-9

Cited by 84 publications

(71 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sulforaphane (SFN), an isothiocyanate obtained from cruciferous vegetables such as broccoli, is one of the most potent naturally occurring Nrf2 activators (Zhang et al, 1992). The fumaric acid ester dimethyl fumarate is also able to stabilize Nrf2 (Spencer et al, 1990), and it has been successfully used for the treatment of psoriasis (Kolbach and Nieboer, 1992). Its oral formulation BG-12 has been recently approved for the treatment of multiple sclerosis (Linker et al, 2011).…”

Section: Nrf2 Activatorsmentioning

confidence: 99%

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

Esteras¹,

Dinkova‐Kostova²,

Abramov³

2016

Biological Chemistry

144

View full text Add to dashboard Cite

Abstract:The nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor wellknown for its function in controlling the basal and inducible expression of a variety of antioxidant and detoxifying enzymes. As part of its cytoprotective activity, increasing evidence supports its role in metabolism and mitochondrial bioenergetics and function. Neurodegenerative diseases are excellent candidates for Nrf2-targeted treatments. Most neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia and Friedreich's ataxia are characterized by oxidative stress, misfolded protein aggregates, and chronic inflammation, the common targets of Nrf2 therapeutic strategies. Together with them, mitochondrial dysfunction is implicated in the pathogenesis of most neurodegenerative disorders. The recently recognized ability of Nrf2 to regulate intermediary metabolism and mitochondrial function makes Nrf2 activation an attractive and comprehensive strategy for the treatment of neurodegenerative disorders. This review aims to focus on the potential therapeutic role of Nrf2 activation in neurodegeneration, with special emphasis on mitochondrial bioenergetics and function, metabolism and the role of transporters, all of which collectively contribute to the cytoprotective activity of this transcription factor.

show abstract

Section: Nrf2 Activatorsmentioning

confidence: 99%

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

Esteras¹,

Dinkova‐Kostova²,

Abramov³

2016

Biological Chemistry

144

View full text Add to dashboard Cite

show abstract

“…Psoriasis vulgaris is a human inflammatory skin disorder, characterized by epidermal hyperplasia with cellular infil trates of lymphocytes and monocytes [5lJ. This disease is thought to be a Thl-associated autoimmune disorder [52,53]. Clinical efficacy of cyclosporin A, CD4 mAb and IL-2 toxin in psoriasis treatment has been well established [51,52].…”

Section: Immumty In Mycobacterial Infectionsmentioning

confidence: 99%

“…This disease is thought to be a Thl-associated autoimmune disorder [52,53]. Clinical efficacy of cyclosporin A, CD4 mAb and IL-2 toxin in psoriasis treatment has been well established [51,52]. These compounds selectively block or eliminate CD4 T-cell activation and expansion.…”

Section: Immumty In Mycobacterial Infectionsmentioning

confidence: 99%

Modulation of Protective and Pathological Immunity in Mycobacterial Infections

Ottenhoff¹,

Spierings²,

Nibbering

et al. 1997

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Mycobacterial infections represent major problems to global health care. Tuberculosis is feared particularly because of its high mortality rates whereas in leprosy the occurrence of immunopathology, particularly nerve damage, is a major problem since the bacillus itself is relatively harmless. Thus, both effective vaccination strategies as well as novel immunomodulating regimens are warranted for the control of morbidity and mortality in mycobacterial diseases. Since CD4⁺ Thl cells and type-1 cytokines play a key role both in protective immunity and immunopathology in mycobacterial infections, we here describe new pharmacological and cytokine-based strategies to regulate Th1 immunity.

show abstract

“…Contraindications are a history of hypertension, hyperlipidbut is associated with numerous side effects including flushing, fatigue, abdominal cramps, lymphocytopenia and hepatitis. Nephrotoxicity is perhaps the most serious side effect of fumaric acid therapy, and acute renal failure has occurred (46). A topical form of fumaric acid is also available but has unproven benefit in the treatment of psoriasis.…”

Section: Cy Closporinmentioning

confidence: 99%