Fumonisin B1 promotes germ cells apoptosis associated with oxidative stress-related Nrf2 signaling in mice testes

Ouyang, Huimin; Zhu, Huquan; Li, Jinhong; Chen, Lina; Zhang, Ruofan; Fu, Qiang; Li, Xinran; Cao, Changyu

doi:10.1016/j.cbi.2022.110009

Cited by 13 publications

(1 citation statement)

References 39 publications

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“…AFB1 could promote cell apoptosis and cell cycle arrest in G2-M phase through oxidative stress, and activate the phosphorylation of nuclear factor-kappa B (NF-ĸB) in microglia in mouse spinal cord to induce cell apoptosis [ 86 ]. Fumonisin (FB1) could also increase the ROS levels of cells by affecting the Keap1-Nrf2 pathway-related factors to cause inflammation and cell apoptosis, and finally destroy the testicular tissue structure and affect the formation of sperm [ 87 ]. In summary, mytoxins can cause apoptosis both in vitro and in vivo.…”

Section: Major Toxicity Mechanisms Induced By Mycotoxins and Heavy Me...mentioning

confidence: 99%

Detoxification of Selenium Yeast on Mycotoxins and Heavy Metals: a Review

Sun

Chen

Xiong

et al. 2023

Biol Trace Elem Res

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Mycotoxins are secondary metabolites produced by specific fungi. More than 400 different mycotoxins are known in the world, and the concentration of these toxins in food and feed often exceeds the acceptable limit, thus causing serious harm to animals and human body. At the same time, modern industrial agriculture will also bring a lot of environmental pollution in the development process, including the increase of heavy metal content, and often the clinical symptoms of low/medium level chronic heavy metal poisoning are not obvious, thus delaying the best treatment opportunity. However, the traditional ways of detoxification cannot completely eliminate the adverse effects of these toxins on the body, and sometimes bring some side effects, so it is essential to find a new type of safe antidote. Trace element selenium is among the essential mineral nutrient elements of human and animal bodies, which can effectively remove excessive free radicals and reactive oxygen species in the body, and has the effects of antioxidant, resisting stress, and improving body immunity. Selenium is common in nature in inorganic selenium and organic selenium. In previous studies, it was found that the use of inorganic selenium (sodium selenite) can play a certain protective role against mycotoxins and heavy metal poisoning. However, while it plays the role of antioxidant, it will also have adverse effects on the body. Therefore, it was found in the latest study that selenium yeast could not only replace the protective effect of sodium selenite on mycotoxins and heavy metal poisoning, but also improve the immunity of the body. Selenium yeast is an organic selenium source with high activity and low toxicity, which is produced by selenium relying on the cell protein structure of growing yeast. It not only has high absorption rate, but also can be stored in the body after meeting the physiological needs of the body for selenium, so as to avoid selenium deficiency again in the short term. However, few of these studies can clearly reveal the protective mechanism of yeast selenium. In this paper, the detoxification mechanism of selenium yeast on mycotoxins and heavy metal poisoning was reviewed, which provided some theoretical support for further understanding of the biological function of selenium yeast and its replacement for inorganic selenium. The conclusions suggest that selenium yeast can effectively alleviate the oxidative damage by regulating different signaling pathways, improving the activity of antioxidant enzymes, reversing the content of inflammatory factors, regulating the protein expression of apoptosis-related genes, and reducing the accumulation of mycotoxins and heavy metals in the body.

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Section: Major Toxicity Mechanisms Induced By Mycotoxins and Heavy Me...mentioning

confidence: 99%