Function of innate lymphoid cells in the immune-related disorders

Džopalić, Tanja; Bozic-Nedeljkovic, Biljana; Jurišić, Vladimir

doi:10.1007/s13577-019-00257-1

Cited by 30 publications

(22 citation statements)

References 98 publications

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“…Until now, the definition and classification of Bregs remain unclear due the lack of unique surface markers. As cell populations can be classified based on cytokine production (26), Breg cells are also classified according to their secreted cytokines in many cases and comprise an assortment of subsets (27). Moreover, the phenotypes of human Bregs are not identical to those of murine Bregs.…”

Section: Phenotypes and Immunoregulatory Functions Of Bregsmentioning

confidence: 99%

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

Shang

Zha²,

Sun

2020

Front. Immunol.

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In immune system, B cells are classically positive modulators that regulate inflammation and immune responses. Regulatory B cells (Bregs) are a subset of B cells which play crucial roles in various conditions, including infection, allergies, autoimmune diseases, transplantation, and tumors. Until now, unequivocal surface markers for Bregs still lack consensus, although numerous Breg subsets have been identified. Generally, Bregs exert their immunoregulatory functions mainly through cytokine secretion and intercellular contact. In the tumor microenvironment, Bregs suppress effector T cells, induce regulatory T cells and target other tumor-infiltrating immune cells, such as myeloidderived suppressor cells, natural killer cells and macrophages, to hamper anti-tumor immunity. Meanwhile, the cross-regulations between Bregs and tumor cells often result in tumor escape from immunosurveillance. In addition, accumulating evidence suggests that Bregs are closely associated with many clinicopathological factors of cancer patients and might be potential biomarkers for accessing patient survival. Thus, Bregs are potential therapeutic targets for future immunotherapy in cancer patients. In this review, we will discuss the phenotypes, functions, and clinical relevance of Bregs in cancer.

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Section: Phenotypes and Immunoregulatory Functions Of Bregsmentioning

confidence: 99%

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

Shang

Zha²,

Sun

2020

Front. Immunol.

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“…ILC2 expressing GATA3, IL‐4, IL‐5, IL‐9 and IL‐13 provides immunity against helminth parasites and the airway inflammation. ILC3 expressing RORγt, IL‐17A and/or IL‐22 functions as a part of defence system against extracellular bacteria, and tissue repair processes 44 …”

Section: Il‐27 Therapy Of Airway Allergies Targets the Innate Immune mentioning

confidence: 99%

“…ILC3 expressing RORγt, IL-17A and/or IL-22 functions as a part of defence system against extracellular bacteria, and tissue repair processes. 44 The ILCs-ILC1 expressing T-bet, IFN-γ and TNF-α, ILC2 expressing GATA3, IL-4, IL-5, IL-9 and IL-13, and ILC3 expressing RORγt, IL-17A and/or IL-22-lack antigen-specific receptors and secrete high amounts of Th cell-related cytokines via antigen-independent stimulation. 44 The patients with asthma and allergic rhinitis and the individuals challenged with a cat allergen show higher frequencies of ILC2 in peripheral blood.…”

Section: Cells (Ilc2)mentioning

confidence: 99%

“…44 The ILCs-ILC1 expressing T-bet, IFN-γ and TNF-α, ILC2 expressing GATA3, IL-4, IL-5, IL-9 and IL-13, and ILC3 expressing RORγt, IL-17A and/or IL-22-lack antigen-specific receptors and secrete high amounts of Th cell-related cytokines via antigen-independent stimulation. 44 The patients with asthma and allergic rhinitis and the individuals challenged with a cat allergen show higher frequencies of ILC2 in peripheral blood. 45 IL-27 reduces ILC2 expansion ( Figure 1D) and IL-4 and IL-13 production by a STAT-1-and STAT-3-dependent and GATA-3-targeted mechanism.…”

Section: Cells (Ilc2)mentioning

confidence: 99%

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The immunomodulatory potentials of interleukin‐27 in airway allergies

et al. 2020

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Allergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen‐induced improper activation and responses of immune and non‐immune cells. One important response is the production of IL‐27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies. IL‐27 exerts powerful modulatory influences on the cells of innate immunity [eg neutrophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells (DCs), innate lymphoid cells (ILCs), natural killer (NK) cells and NKT cells)] and adaptive immunity (eg Th1, Th2, Th9, Th17, regulatory T, CD8+ cytotoxic T and B cells). The IL‐27‐mediated signalling pathways may be modulated to attenuate asthma and allergic rhinitis. In this review, a comprehensive discussion concerning the roles carried out by IL‐27 in asthma and allergic rhinitis was provided, while evidences are presented favouring the use of IL‐27 in the treatment of airway allergies.

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“…Innate lymphoid cells (ILCs) play a main role in immune-related disorders and are divided into three groups: ILC1s, ILC2s, and ILC3s (1). Natural killer (NK) cells, which belongs to the ILC1 group, are bone marrow derived cytotoxic lymphocytes (CL) that are well-equipped for the destruction of target cells without the need for prior antigen stimulation.…”

Section: Introductionmentioning

confidence: 99%

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

et al. 2020

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The innate lymphocyte lineage natural killer (NK) is now the target of multiple clinical applications, although none has received an agreement from any regulatory agency yet. Transplant of naïve NK cells has not proven efficient enough in the vast majority of clinical trials. Hence, new protocols wish to improve their medical use by producing them from stem cells and/or modifying them by genetic engineering. These techniques have given interesting results but these improvements often hide that natural killers are mainly that: natural. We discuss here different ways to take advantage of NK physiology to improve their clinical activity without the need of additional modifications except for in vitro activation and expansion and allograft in patients. Some of these tactics include combination with monoclonal antibodies (mAb), drugs that change metabolism and engraftment of specific NK subsets with particular activity. Finally, we propose to use specific NK cell subsets found in certain patients that show increase activity against a specific disease, including the use of NK cells derived from patients.

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Function of innate lymphoid cells in the immune-related disorders

Cited by 30 publications

References 98 publications

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer

The immunomodulatory potentials of interleukin‐27 in airway allergies

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

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