XIth International Congress on Thrombosis and Haemostasis 1987
DOI: 10.1055/s-0038-1644634
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Function of Platelet 47k Phosphoprotein

Abstract: Secretion of platelet granule constituents is closely associated with the phosphorylation of a cytosol polypeptide that we called P47 of Mr 47,000 (Imaoka, T. and Haslam, R.J., J. Biol. Chem. 258, 11404, 1983), by protein kinase C. Since the identity and function remains to be known, we purified protein kinase C, unphosphorylated and phosphorylated P47 to homogeneity from human platelets. Then precise phosphorylation reaction of P47 in vitro and a biological function of P47 were studied. Protein kinase C catal… Show more

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“…Reductions of Ca 2+ concentration in erythrocyte membranes, platelet cells and synapsis membranes of neuronal cells have been recorded (Imaoka 1987). Decreases of 33.7, 17.2 and 18.5% of calcium, associated with rises of 25.0, 7.9 and 38.6% of sodium in hearts, erythrocytes and plasmas of spontaneously hypertensive rats also agree with those recent results.…”
Section: Detection Limits"supporting
confidence: 80%
“…Reductions of Ca 2+ concentration in erythrocyte membranes, platelet cells and synapsis membranes of neuronal cells have been recorded (Imaoka 1987). Decreases of 33.7, 17.2 and 18.5% of calcium, associated with rises of 25.0, 7.9 and 38.6% of sodium in hearts, erythrocytes and plasmas of spontaneously hypertensive rats also agree with those recent results.…”
Section: Detection Limits"supporting
confidence: 80%