Functional alterations in bipartite network of white and grey matters during aging

Gao, Yurui; Zhao, Yu; Li, Muwei; Lawless, Richard D.; Schilling, Kurt G.; Xu, L.; Shafer, Andrea T.; Beason‐Held, Lori L.; Resnick, Susan M.; Rogers, Baxter P.; Ding, Zhaohua; Anderson, Adam W.; Landman, Bennett A.; Gore, John C.

doi:10.1016/j.neuroimage.2023.120277

Cited by 7 publications

(4 citation statements)

References 73 publications

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“…The linear age effects show significant positive correlations primarily in WM1, WM2, WM3, and WM8. These networks, specifically WM2, WM3, and WM8, are part of the middle-deep layer networks involving the corona radiata and longitudinal fasciculus systems, consistent with a recent study reporting an age-related positive correlation between the average connectivity strength of the bilateral anterior corona radiata and left superior longitudinal fasciculus with the whole GM region (Gao et al, 2023). Abnormal connectivity between gray matter and the corona radiata has been reported in neurodegenerative diseases (Wang et al, 2022).…”

Section: Discussionsupporting

confidence: 88%

“…Two types of age effects, positive correlations, and inverted U-shaped age effects, are observed in static FNC from the perspective of each FNC pair, similar to a recent study (Gao et al, 2023). In contrast, the analysis of dynamic FNC variability shows two opposite age effects: negative correlations and positive U-shaped age effects.…”

Section: Discussionsupporting

confidence: 85%

“…Secondly, the absence of cognitive ability test data from participants limits the interpretation and generalizability of our findings. Lastly, We did not examine a symmetric adjacency matrix combining GM-and WM-FNs due to their distinct connectivity patterns and potential differences in neural mechanisms and amplitudes (Gao et al, 2023;Gore et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Using independent component analysis to group WM voxels into spatially distinct functional units, researchers have found that FCs within and among those units decrease significantly with aging (Li et al, 2023). Another recent study revealed three age effects on WM-GM FC pairs including a negative linear age effect, a positive linear age effect and an inverted-U-shaped age effect (Gao et al, 2023). Nevertheless, we still have limited knowledge regarding the age effects on WM function, especially in terms of the brain dynamics which have been demonstrated to be robust and reliable (Basile et al, 2022;Wang et al, 2021a;Zhang et al, 2021a).…”

Section: Introductionmentioning

confidence: 99%

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Static and Dynamic Connectivity Structure of White-Matter Functional Network across the Adult Lifespan

Linli,

Hu,

Guo

et al. 2024

Preprint

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Background. The maturation and ageing of the human brain involve intricate biological processes that result in complex changes in brain structure and function. Although the effects of aging on functional connectivity within gray matter (GM) regions have been extensively studied, the investigation of white matter (WM) functional changes remains limited. Methods. In this study, our aim was to investigate age-related trajectory in WM functional dynamics using resting-state functional magnetic resonance imaging (rs-fMRI) data from a large lifespan sample of 494 individuals. First, GM and WM functional networks (FNs) were identified by k-means clustering. Next, we performed static and dynamic analysis of WM functional network connectivity (FNC) to explore age effect on WM-FNs. Furthermore, we investigated recurrent patterns of dynamic FNC. Finally, we conducted several validation analyses to ensure replicability. Results. We identified 9 reliable WM and 12 GM FNs. The findings revealed age-related effects on WM FNC strength and WM-GM FNC dynamics, primarily including linear positive and U-shaped age trajectories in static FNC strength, as well as linear negative and inverted U-shaped age trajectories in FNC temporal variability. Additionally, we identified three distinct brain states with significant age-related differences. The aforementioned findings were largely replicated in the validation analysis. Conclusion. High integration and low temporal variability in WN-GM FNC may reflect a less efficient network system in older adults. These findings enhance our understanding of brain aging processes and provide insights into the trajectory of WM functional dynamics during normal ageing.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Static and Dynamic Connectivity Structure of White-Matter Functional Network across the Adult Lifespan

Linli,

Hu,

Guo

et al. 2024

Preprint

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Reductions in the white–gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition

Xu,

Zhao,

Choi

et al. 2024

Alzheimer's & Dementia

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BACKGROUNDThe magnitudes and patterns of alterations of the white–gray matter (WM–GM) functional connectome in preclinical Alzheimer's disease (AD), and their associations with amyloid and cognition, remain unclear.METHODSWe compared regional WM–GM functional connectivity (FC) and network properties in subjects with preclinical AD (or AD dementia) and controls (total n = 344). Their associations with positron emission tomography AV45‐measured amyloid beta (Aβ) load and modified Preclinical Alzheimer Cognitive Composite (mPACC) scores were examined.RESULTSPreclinical AD subjects showed lower FC in specific WM–GM pairs and reduced segregation of control, dorsal attention, and somatomotor networks. A major portion of the reduced FC and network segregations were linked to elevated Aβ. Reduced FC of one WM–GM pair correlated with impaired mPACC. AD dementia exhibited broader reductions and stronger associations.DISCUSSIONThe WM–GM functional connectome undergoes regional and systemic dysfunctions as early as in the preclinical stage, correlating with amyloid deposition and predicting cognitive impairment.Highlights Preclinical Alzheimer's disease (AD) subjects showed lower functional connectivity in specific white‐gray matter (WM–GM) pairs and reduced segregations of control, dorsal attention, and somatomotor networks. A major portion of the reduced connectivity and network segregations were linked to elevated amyloid beta load. Only one WM–GM pair's reduced connectivity was linearly correlated with impaired cognitive composite scores. AD dementia showed more extensive reductions in connectivity, network integration, and segregation, with stronger associations with amyloid elevation and cognitive impairment. The WM–GM functional connectome offers a distinct perspective for understanding changes in brain functional architecture throughout the AD continuum.

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Functional correlation tensors in brain white matter and the effects of normal aging

Xu,

Gao,

et al. 2024

Brain Imaging and Behavior

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Resting state correlations between blood oxygenation level dependent (BOLD) MRI signals from voxels in white matter (WM) are demonstrably anisotropic, so that functional correlation tensors (FCT) may be used to quantify the underlying microstructure of BOLD effects in WM tracts. However, the overall spatial distribution of FCTs and their metrics in specific populations has not yet been established, and the factors that affect their precise arrangements remain unclear. Changes in WM occur with normal aging, and these may be expected to affect FCTs. We hypothesized that FCTs exhibit a characteristic spatial pattern and may show systematic changes with aging or other factors. Here we report our analyses of the FCT characteristics of fMRI images of a large cohort of 461 cognitively normal subjects (190 females, 271 males) sourced from the Open Access Series of Imaging Studies (OASIS), with age distributions of 42 y/o – 95 y/o. Group averages and statistics of FCT indices, including axial functional correlations, radial functional correlations, mean functional correlations and fractional anisotropy, were quantified in WM bundles defined by the JHU ICBM-DTI-81 WM atlas. In addition, their variations with normal aging were examined. The results revealed a dimorphic distribution of changes in FCT metrics with age, with decreases of the functional correlations in some regions and increases in others. Supplementary analysis revealed that females exhibited significant age effects on a greater number of WM areas, but the interaction between age and sex was not significant. The findings demonstrate the reproducibility of the spatial distribution of FCT metrics and reveal subtle regional changes with age.

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Functional alterations in bipartite network of white and grey matters during aging

Cited by 7 publications

References 73 publications

Static and Dynamic Connectivity Structure of White-Matter Functional Network across the Adult Lifespan

Static and Dynamic Connectivity Structure of White-Matter Functional Network across the Adult Lifespan

Reductions in the white–gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition

Functional correlation tensors in brain white matter and the effects of normal aging

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