Functional analysis and associated factors of the peripapillary retinal nerve fibre layer in former preterm and full-term infants

Fieß, Achim; Christian, Luka; Janz, Johannes; Kölb-Keerl, Ruth; Knuf, Markus; Kirchhof, Bernd; Muether, Philipp S.; Bauer, Jacqueline

doi:10.1136/bjophthalmol-2016-309622

Cited by 34 publications

(41 citation statements)

References 23 publications

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“…Peripapillary circle SD-OCT scans were implemented centred on the optic disc using eye tracking with high axial resolution of 4 lm as reported earlier (Fieß et al 2017a). Only pRNFL measurements of good SD-OCT signal strength without movement or acquisition artefacts were included.…”

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

“…In previous studies which measured peripapillary RNFL thickness in former preterm infants with SD-OCT, low birth weight (Tariq et al 2011;Fieß et al 2017a), low GA (Wang et al 2012;Fieß et al 2017a) and stage of ROP (Park & Oh 2015) were identified as the main factors influencing pRNFL thinning. Furthermore, McLoone et al (2006) observed a hypoplastic optic nerve via RetCam (Clarity Medical Systems) in preterm infants with stage IV intraventricular bleeding imaged at 33-34 weeks of GA.…”

Section: Changes In the Optic Nervementioning

confidence: 99%

“…Only pRNFL measurements of good SD-OCT signal strength without movement or acquisition artefacts were included. Peripapillary circle SD-OCT scans were implemented centred on the optic disc using eye tracking with high axial resolution of 4 lm as reported earlier (Fieß et al 2017a). When the SD-OCT was not possible, another measurement was attempted.…”

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

“…The optic nerve is part of the central nervous system, and currently, peripapillary retinal nerve fibre layer (pRNFL) measurements can non-invasively provide quantitative and qualitative information about the central nervous tissue. Furthermore, in the WPS, an association between pRNFL thinning and reduced visual acuity was found (Fieß et al 2017a). Similarly, the Wiesbaden Prematurity Study (WPS) investigating former preterm and full-term children at age 4-10 years has demonstrated an association of pRNFL thinning with low birthweight as well as low gestational age (GA).…”

Section: Introductionmentioning

confidence: 96%

“…Similarly, the Wiesbaden Prematurity Study (WPS) investigating former preterm and full-term children at age 4-10 years has demonstrated an association of pRNFL thinning with low birthweight as well as low gestational age (GA). Furthermore, in the WPS, an association between pRNFL thinning and reduced visual acuity was found (Fieß et al 2017a). Therefore, it is of interest if these pRNFL measurements reveal information about infants' neurologic development.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Fieß

Kölb-Keerl

Schuster³

et al. 2018

Acta Ophthalmologica

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Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

Section: Changes In the Optic Nervementioning

confidence: 99%

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Fieß

Kölb-Keerl

Schuster³

et al. 2018

Acta Ophthalmologica

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Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

et al. 2022

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IMPORTANCEPreterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes.OBJECTIVE To evaluate the association between preterm infant retinal microanatomy and VA at 9 months' corrected age. DESIGN, SETTING, AND PARTICIPANTSThis prospective observational study took place from November 2016 and December 2019 at a single academic medical center and included preterm infants enrolled in Study of Eye Imaging in Preterm Infants (BabySTEPS). Infants were eligible for enrollment in BabySTEPS if they met criteria for retinopathy of prematurity (ROP) screening, were 35 weeks' postmenstrual age or older at the time of first OCT imaging, and a parent or guardian provided written informed consent. Of 118 infants enrolled in BabySTEPS, 61 were included in this analysis. Data were analyzed from March to April 2021. EXPOSURES Bedside optical coherence tomography (OCT) imaging at a mean (SD) 39.85 (0.79) weeks' postmenstrual age and monocular grating VA measurement at 9 months' corrected age. MAIN OUTCOMES AND MEASURESPresence and severity of macular edema and presence of ellipsoid zone at the fovea measured by extracting semiautomated thicknesses of inner nuclear layer, inner retina, and total retina at the foveal center; choroid across foveal 1 mm; and retinal nerve fiber layer (RNFL) across the papillomacular bundle (PMB). Pearson correlation coefficients were calculated and 95% CIs were bootstrapped for the association between retinal layer thicknesses and continuous logMAR VA. Associations were analyzed between retinal microanatomy and normal (3.70 cycles/degree or greater) vs subnormal grating VA at 9 months' corrected age using logistic regression and with logMAR VA using linear regression, adjusting for birth weight, gestational age, and ROP severity at the time of OCT imaging and accounting for intereye correlation using generalized estimating equations. RESULTSThe mean (SD; range) gestational age of included infants was 27.6 (2.8; 23.0-34.6) weeks, and mean (SD; range) birth weight was 958.2 (293.7; 480-1580) g. In 122 eyes of 61 infants, the correlations between retinal layer thicknesses and logMAR VA were as follows: r, 0.01 (95% CI, −0.07 to −0.27) for inner nuclear layer; r, 0.19 (95% CI, 0.01 to 0.35) for inner retina; r, 0.15 (95% CI, −0.02 to 0.31) for total retina; r, −0.22 (95% CI, −0.38 to −0.03) for choroid; and r, −0.27 (95% CI, −0.45 to 0.10) for RNFL across the PMB. In multivariable analysis, thinner RNFL across the PMB (regression coefficient, −0.05 per 10-μm increase in RNFL thickness; 95% CI, −0.10 to −0.01; P = .046) and prior ROP treatment (regression coefficient, 0.33 for ROP treatment; 95% CI, 0.11 to 0.56; P = .003) were independently associated with poorer 9-month logMAR VA. CONCLUSIONS AND RELEVANCEIn preterm infants, RNFL thinning across the PMB was associated with poorer 9-month VA, independent of birth weight, gestational age, need for ROP treatment, and macular microanatom...

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Ophthalmological long-term sequelae of premature birth—Persisting into adulthood

et al. 2023

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Functional analysis and associated factors of the peripapillary retinal nerve fibre layer in former preterm and full-term infants

Abstract: The main factors for retinal nerve fibre layer thinning are low birth weight and low GA. In addition, decreased RNFLT was associated with reduced visual function. This demonstrates that preterm infants are at high risk for peripapillary RNFL damage associated with reduced visual function.

Cited by 34 publications

References 23 publications

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

Ophthalmological long-term sequelae of premature birth—Persisting into adulthood

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