Functional and morphological effects of repeated sodium arsenite exposure on rat peripheral sensory nerves

García-Chávez, Erika; Segura, Bertha; Merchant, Hugo; Jiménez, Ismael; Razo, Luz M. Del

doi:10.1016/j.jns.2007.03.007

Cited by 29 publications

(23 citation statements)

References 26 publications

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“…The arsenic + quercetin group rats were given 10 mg kg À1 sodium arsenite and 50 mg kg À1 quercetin (Quercetin, Sigma-Aldrich Quercetin ≥95% (HPLC), solid Steinheim, Germany) via intragastric gavage every day for 15 days. Doses of arsenic (Garcia-Chavez et al, 2007;Fouad et al, 2011;) and quercetin (Erden Inal & Kahraman, 2000;Ikizler et al, 2007) were determined according to the literature.…”

Section: Experimental Procedures and Specimen Collectionmentioning

confidence: 99%

“…Even in low doses, arsenic leads to oxidative DNA damage (Schwerdtle et al, 2003;Kubota et al, 2006) and formation of reactive oxygen and nitrogen types which result in lipid peroxidation (Pi et al, 2002;Garcia-Chavez et al, 2007). In addition, an increasing number of experimental studies have shown that arsenic causes endocrine disruptions, change in cell cycle kinetics, epigenetic effects and change in transcription (NRC, 2001;Kitchin & Wallace, 2005;Davey et al, 2007;Reichard et al, 2007;Coppin et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of quercetin against arsenic-induced testicular damage in rats

et al. 2016

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This study investigated the effect of quercetin on changes in testes due to arsenic exposure. Twenty-seven male rats were divided into three groups: control (10 ml kg day saline), arsenic (10 mg kg day sodium arsenite) and arsenic + quercetin (arsenic + 50 mg kg day quercetin). The rats were sacrificed at the end of 15-day experiment. There was no difference between control group and arsenic group in body weight gain, testicular weight and serum total testosterone level. Quercetin treatment did not cause a significant difference in these parameters. In the arsenic group rats, we determined deterioration in the structure of seminiferous tubules, a decrease in the number of spermatogenic cells, an increase in the number of apoptotic cells, a decrease in the number of PCNA-positive cells, a decrease in SOD, CAT and GSH-Px activities, and an increase in the MDA level in testicular tissue. In all these changes, arsenic+quercetin group showed an improved compared to arsenic group. The amount of arsenic increased in the arsenic group was compared to the control group, and there was no difference between arsenic group and arsenic + quercetin group in the amount of arsenic. In conclusion, quercetin prevented arsenic-induced testicular damage with its anti-apoptotic and antioxidant effects.

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Section: Experimental Procedures and Specimen Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of quercetin against arsenic-induced testicular damage in rats

et al. 2016

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“…in [13] lengthened latency of the pattern reversal visual eps and various peripheral nerve abnormalities more frequently observed in as-exposed workers of a copper smelter than in nonexposed control employees of the same factory. in as-exposed rats, slowed conduction velocity of the sural nerve, and massive deposition of as, was seen [10]. also in rats, as load resulted in decreased of motility [33,38].…”

Section: Electrophysiologymentioning

confidence: 84%

“…Workers in a copper smelter, exposed by the arsenic content of the ore processed, showed alterations of the eeg patterns, visual evoked potentials, and peripheral nerve action potentials [13]. such effects of as have also been modeled in animals [10,33,35].…”

mentioning

confidence: 99%

Rutin, a flavonoid phytochemical, ameliorates certain behavioral and electrophysiological alterations and general toxicity of oral arsenic in rats

Sárközi¹,

Papp²,

Máté³

et al. 2015

Acta Biologica Hungarica

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department of public health, university of szeged faculty of medicine, dóm tér 10, h-6720 szeged, hungary (Received: may 5, 2014; accepted: June 23, 2014) arsenic affects large populations and attacks, among others, the nervous system. Waterborne or occupational exposure causes electrophysiological alterations and motor disturbances in humans, and analogous effects were found in animals. certain phytochemicals may be protective against as-caused damages.In the present study it was investigated whether the flavonoid rutin, applied via the drinking water (2 g/L), ameliorates the effects of arsenic given by gavage (10 mg/kg b.w., in form of NaAsO 2 ) on open field motility, evoked cortical and peripheral electrophysiological activity, and body weight gain in adult male Wistar rats. Body weight gain was significantly reduced from the 4 th week of the 6 weeks arsenic treatment and this effect was largely abolished by rutin in the combination treatment group. Rats treated by arsenic alone showed decreased open field motility; latency of the cortical evoked potentials increased and peripheral nerve conduction velocity decreased. these functional alterations were also counteracted by co-administration of rutin, and both the antioxidant and the chelating activity of rutin might have contributed to the ameliorative effect. these results are apparently novel and support the potential role of natural agents in preserving human health in a contaminated environment.

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“…Some alterations have been observed after a short intraperitoneal infusion of arsenite (6 days, Dhar et al, 2007), after 1 month of heavy oral exposure (10 mg/kg, García-Chávez et al, 2007) or in cell cultures in vitro (Jin et al, 2004). Since oxidative stress is a well-demonstrated mechanism of arsenic toxicity (Hughes, 2002), morphological alterations have been attributed to damage through reactive oxygen species.…”

Section: Introductionmentioning

confidence: 99%

Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats

et al. 2009

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Functional and morphological effects of repeated sodium arsenite exposure on rat peripheral sensory nerves

Cited by 29 publications

References 26 publications

Protective effects of quercetin against arsenic-induced testicular damage in rats

Protective effects of quercetin against arsenic-induced testicular damage in rats

Rutin, a flavonoid phytochemical, ameliorates certain behavioral and electrophysiological alterations and general toxicity of oral arsenic in rats

Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats

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