Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Project
Abstract:This cross-sectional study evaluated the relationship between ) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enrolled in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR) study (NCT01726075). Functional studies by multifocal electroretinography (mfERG) evaluated neurodysfunct… Show more
“…Each patient underwent a comprehensive ophthalmic examination as previously reported (15). Only one eye from each patient was included in the study.…”
Section: Methodsmentioning
confidence: 99%
“…Eligibility criteria were age between 45 and 75 years, a diagnosis of type 2 diabetes with a known duration $5 years, and an Early Treatment for Diabetic Retinopathy Study (ETDRS) level of #35. Exclusion criteria were previously detailed (15).…”
Section: Study Design and Participantsmentioning
confidence: 99%
“…The mfERGs were recorded in the study eye using the RETI-port/scan21 (Roland Consult, Berlin, Germany) visual electrophysiology system. Detailed information regarding the methodology used has been previously reported (15).…”
Section: Mferg Recording and Analysismentioning
confidence: 99%
“…A total of 284 patients underwent CIRRUS HD-OCT imaging, and 165 patients underwent Topcon 3D-OCT 2000 imaging. Further details on the methodology have been previously reported (15).…”
Section: Optical Coherence Tomography Imaging and Analysismentioning
Clinical trial reg. no. NCT01726075, clinicaltrials.gov This article contains Supplementary Data online at http://diabetes .diabetesjournals.org/lookup/suppl/
“…Each patient underwent a comprehensive ophthalmic examination as previously reported (15). Only one eye from each patient was included in the study.…”
Section: Methodsmentioning
confidence: 99%
“…Eligibility criteria were age between 45 and 75 years, a diagnosis of type 2 diabetes with a known duration $5 years, and an Early Treatment for Diabetic Retinopathy Study (ETDRS) level of #35. Exclusion criteria were previously detailed (15).…”
Section: Study Design and Participantsmentioning
confidence: 99%
“…The mfERGs were recorded in the study eye using the RETI-port/scan21 (Roland Consult, Berlin, Germany) visual electrophysiology system. Detailed information regarding the methodology used has been previously reported (15).…”
Section: Mferg Recording and Analysismentioning
confidence: 99%
“…A total of 284 patients underwent CIRRUS HD-OCT imaging, and 165 patients underwent Topcon 3D-OCT 2000 imaging. Further details on the methodology have been previously reported (15).…”
Section: Optical Coherence Tomography Imaging and Analysismentioning
Clinical trial reg. no. NCT01726075, clinicaltrials.gov This article contains Supplementary Data online at http://diabetes .diabetesjournals.org/lookup/suppl/
“…However, neurodegeneration is not a dominant pathogenic factor in all patients. What is more, diabetic retinopathy develops in diabetic patients in various manners, and its three phenotypes have been differentiated depending on progression and risk of vision loss [94,95]. Following the revolution in pathogenesis, there appear new possibilities in treatment of diabetic retinopathy.…”
Section: Treatment Of Diabetic Retinopathymentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.