2021
DOI: 10.1007/s42770-021-00497-0
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Functional and tissue enrichment analyses suggest that SARS-CoV-2 infection affects host metabolism and catabolism mediated by interference on host proteins

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(1 citation statement)
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“…Besides, SARS-CoV-2 S protein can activate reactive oxygen species (ROS)-inhibited phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) pathways, 39 subsequently inducing autophagy-triggered apoptosis and inflammation. 40 42 It is noteworthy that SARS-CoV-2 has weaker pro-apoptotic activity than SARS-CoV, 32 , 43 which may partially explain the more cases of asymptomatic patients with widespread viral transmission. Mutations of SARS-CoV-2 ORF3a attenuate cytosolic form-related apoptosis, whereas SARS-CoV ORF3a could well leverage this way.…”
Section: Apoptosis and Sars-cov-2mentioning
confidence: 99%
“…Besides, SARS-CoV-2 S protein can activate reactive oxygen species (ROS)-inhibited phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) pathways, 39 subsequently inducing autophagy-triggered apoptosis and inflammation. 40 42 It is noteworthy that SARS-CoV-2 has weaker pro-apoptotic activity than SARS-CoV, 32 , 43 which may partially explain the more cases of asymptomatic patients with widespread viral transmission. Mutations of SARS-CoV-2 ORF3a attenuate cytosolic form-related apoptosis, whereas SARS-CoV ORF3a could well leverage this way.…”
Section: Apoptosis and Sars-cov-2mentioning
confidence: 99%