2017
DOI: 10.1038/s41598-017-15822-7
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Functional annotation of structural ncRNAs within enhancer RNAs in the human genome: implications for human disease

Abstract: Enhancer RNAs (eRNAs) are a novel class of non-coding RNA (ncRNA) molecules transcribed from the DNA sequences of enhancer regions. Despite extensive efforts devoted to revealing the potential functions and underlying mechanisms of eRNAs, it remains an open question whether eRNAs are mere transcriptional noise or relevant biologically functional species. Here, we identified a catalogue of eRNAs in a broad range of human cell/tissue types and extended our understanding of eRNAs by demonstrating their multi-omic… Show more

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Cited by 26 publications
(27 citation statements)
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References 107 publications
(132 reference statements)
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“…In addition to primary structure heterogeneity, eRNAs demonstrate diverse secondary structures that model those seen in tRNAs, miRNAs, snRNAs, and lncRNAs (Cheng et al, 2015;Ren et al, 2017). Some eRNA molecules contain different domains with unique functions (Cajigas et al, 2018;Cichewicz et al, 2018;Tsai et al, 2018).…”
Section: Structure and Heterogeneity Of Ernamentioning
confidence: 99%
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“…In addition to primary structure heterogeneity, eRNAs demonstrate diverse secondary structures that model those seen in tRNAs, miRNAs, snRNAs, and lncRNAs (Cheng et al, 2015;Ren et al, 2017). Some eRNA molecules contain different domains with unique functions (Cajigas et al, 2018;Cichewicz et al, 2018;Tsai et al, 2018).…”
Section: Structure and Heterogeneity Of Ernamentioning
confidence: 99%
“…Nevertheless, emerging evidence implicates a role for eRNA itself in transcription regulation. On a genomic scale, eRNA transcription and induction of mRNA transcription at neighboring genes are correlated (Kim et al, 2010;Kaikkonen et al, 2013;Li et al, 2013;Andersson et al, 2014a;Arner et al, 2015;Cheng et al, 2015;Dorighi et al, 2017;Ren et al, 2017;Imamura et al, 2018). RNAP II is not only abundantly present at active enhancers, but appears to be critical to their function as ubiquitination and dismissal of RNAP II leads to enhancer decommission and downregulation of target genes (Tan et al, 2018).…”
Section: Biological Functions Of Erna Erna As Regulators Of Gene Exprmentioning
confidence: 99%
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