2024
DOI: 10.1101/2024.04.29.591611
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Functional Biosynthetic Stereodivergence in a Gene Cluster via a DihydrosydnoneN-oxide

Jiajun Ren,
Anugraha Mathew,
Maria Rodriguez Garcia
et al.

Abstract: Chirality features a critical role in the biochemistry of life and often only one enantiomeric series is observed (homochirality). Only few natural products have been obtained as racemates, e.g. the quorum-sensing signal valdiazen produced by Burkholderia cenocepacia H111. In this study, we investigated its biosynthetic gene cluster and discovered that both the enantiomerically pure (R)–fragin and the racemic valdiazen are obtained from the same pathway. This stereodivergence is based on the unusual heterocycl… Show more

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