Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy

Yang, Xiaoyan; Wang, Dongya; Zhu, Jiawei; Xue, Lei; Ou, Changjin; Wang, Wenjun; Lü, Min; Song, Xuejiao; Dong, Xiaochen

doi:10.1039/c8sc04844d

Cited by 158 publications

(103 citation statements)

References 52 publications

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“…Phototherapy mainly includes photothermal therapy (PTT) and photodynamic therapy (PDT) . PTT utilizes photoabsorbing agents to perform hyperthermia‐induced cell death while PDT adopts the photosensitizers to generate cytotoxic reactive oxygen species (ROS) . Nano‐BP has been at the center of tremendous research on their application to PTT as well as PDT owing to their unique optoelectronic properties …”

Section: Biomedical Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

200

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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Section: Biomedical Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

200

115

View full text Add to dashboard Cite

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“…In order to evaluate the antitumor efficacy of PMCZ, the HeLa tumor-bearing mice were randomly divided into six groups for different treatments, i.e., (1) PBS, (2) PMCZ, PMCZ + PDT (3), PMCZ + PTT (4), PMZ + PDT + PTT (5), and PMCZ + PDT + PTT (6). The tumor size was measured each day and these differently treated tumors were harvested for weighing and photographing at the end of 14 day treatment.…”

Section: In Vitro Cytotoxicity and Therapeutic Investigation Of The Pmentioning

confidence: 99%

“…The construction of a multifunctional nanoplatform with integrated PDT and PTT could enhance the therapeutic performance of the corresponding monotherapy. [1][2][3][4][5][6] However, the oxygen (O 2 )-dependent PDT of combination phototherapy usually showed unsatisfying therapeutic effects on hypoxic solid tumors because of the inadequate O 2 supply in tumor vascular systems. [7][8][9][10][11][12][13] Another key restraint of potent combination phototherapy originates from lacking specicity towards hypoxic tumor tissue administration, resulting in nonspecic responsibility for causing undesired damage of adjacent healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

An intelligent ZIF-8-gated polydopamine nanoplatform for in vivo cooperatively enhanced combination phototherapy

Feng

et al. 2020

Chem. Sci.

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“…Amongst, thermal decomposition is the most developed and widely used method for the construction of MIONs with precisely controlled sizes and morphologies 15 . This “control” is of vital importance for biomedical applications because the physicochemical properties and nano‐bio interactions of nanomedicines strongly depend on their structures 16,17 . As the crystal size of MIONs decreases below a certain value (∼20 nm), the energy barrier caused by magnetic anisotropy will be overcome by thermal fluctuation, resulting in the superparamagnetism.…”

Section: Magnetic Iron Oxide Nanomaterialsmentioning

confidence: 99%

Magnetic iron oxide nanomaterials: A key player in cancer nanomedicine

Liang

Zhang

Cheng

et al. 2020

VIEW

Self Cite

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Magnetic iron oxide nanomaterials are among the most widely studied candidates for cancer nanomedicine, because of not only their great biocompatibility and abundance of raw materials, but also their diverse physicochemical properties and biological effects. Represented by magnetite and maghemite, various iron oxide‐based magnetic nanomaterials have been developed for cancer diagnosis and treatment. This mini review presents an up‐to‐date overview of magnetic iron oxide‐based cancer nanomedicines with an emphasis on bioimaging and therapy.

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Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy

Abstract: A mitochondria-targeting nanosystem, BP@PDA–Ce6&TPP NSs, has been constructed, and exhibit excellent performance in imaging-guided synergistic photothermal and photodynamic cancer therapy.

Cited by 158 publications

References 52 publications

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

An intelligent ZIF-8-gated polydopamine nanoplatform for in vivo cooperatively enhanced combination phototherapy

Magnetic iron oxide nanomaterials: A key player in cancer nanomedicine

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