Functional changes in the sleep-wake cycle after experimental traumatic brain injury

Гаврилов, Ю. В.; Деревцова, К. З.; Корнева, Е. А.

doi:10.25557/2310-0435.2019.01.50-55

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Чаще всего больные жаловались на прерывистый сон и тяжесть в голове после сна, а также на желание поспать днем. В более ранних исследованиях, выполненных на экспериментальных животных, также было отмечено увеличение продолжительности дневного сна при ЧМТ [2].…”

Section: результаты исследования и их обсуждениеunclassified

“…По данным литературы, частыми последствиями ЧМТ являются диссомнические расстройства, бесспорно, влияющие на качество жизни. Нарушения сна, возникшие в посттравматическом периоде, существенно сказываются на когнитивной активности и затрудняют реабилитационный потенциал пациентов, что приводит к последующему снижению трудоспособности и качества жизни людей при их возвращении к нормальной социально-бытовой жизни [2,4,6]. Нарушения сна достаточно хорошо описаны в мировой медицинской литературе, выявлены различные синдромы, такие как гиперсомния, бессонница, парасомния или изменения циркадного ритма.…”

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Insomniac disorders in patients with traumatic brain injury complicated with subdural hematoma

Balandin¹,

Balandina²,

Pankratov

2021

Humans and their Health

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The objective: to determine the frequency of insomniac disorders in patients with traumatic brain injury (TBI) complicated with subdural hematoma, for early detection and prevention of sleep disorders in recovery periods. Materials and methods. A survey was conducted in 102 patients with TBI complicated with acute subdural hematoma who were operated on in the Neurosurgical Department of the M.A. Tverye State medical center in Perm in the period from 2018 to 2019. The study included patients with the most frequent localization of subdural hematoma. Group I consisted of 31 patients (30%) with a hematoma localized in the frontotemporal region, group II - 28 patients (27%) with a hematoma localized in the parietal - temporal region, group III - 18 patients (18%) with a hematoma localized in the frontotemporal - occipital region, group IV - 25 patients (25%) with a hematoma localized in the parietal-occipital region. On day 13-14 after surgical intervention to remove the subdural hematoma, the patients were interviewed using the ISI scale to determine the presence and severity of insomnia. Results. The severity of condition on admission was assessed as 13-12 points on the Glasgow scale in the largest number of patients. The most severe general condition on admission was noted in patients with subdural hematoma localized in the frontal-parietal-occipital area. Out of 102 patients, only one patient was found to have moderate sleep disturbances when assessing the insomnia severity index and 13 patients were found to have mild sleep disturbances. The most common complaints of the patients when interviewed were a feeling of heaviness in the head after sleep, intermittent, shallow sleep. Conclusion. Interrupted sleep and heaviness in the head afterwards, as well as the need for daytime sleep, are the most frequent complaints about the sleep process in patients with a traumatic brain injury complicated with a subdural hematoma on the 13th-14th day after injury.

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Section: результаты исследования и их обсуждениеunclassified

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Insomniac disorders in patients with traumatic brain injury complicated with subdural hematoma

Balandin¹,

Balandina²,

Pankratov

2021

Humans and their Health

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Insomniac and cognitive disorders as a manifestation of encephalopathy during chemotherapy

Balandin,

Ovchinnikova,

Balandina

2024

Medicinskij sovet

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Introduction. Chemotherapy is currently the mainstay of treatment for patients with cancer, but despite its high efficacy, it has a number of drawbacks. With many interesting studies on chemotherapy-associated encephalopathy, absolutely no attention is paid to insomniac problems, which can also be “red buttons” for triggering cognitive and emotional disorders.Aim. To identify the features of neurological disorders in the form of dyssomnias and cognitive disorders in patients receiving chemotherapy.Materials and methods. The work was conducted in the chemotherapy department and was based on the results of the examination of 50 women undergoing chemotherapy courses with a diagnosis of malignant breast neoplasm. The study sample Introduction. Chemotherapy is currently the mainstay of treatment for patients with cancer, but despite its high efficacy, it has a number of drawbacks. With many interesting studies on chemotherapy-associated encephalopathy, absolutely no attention is paid to insomniac problems, which can also be “red buttons” for triggering cognitive and emotional disorders.Aim. To identify the features of neurological disorders in the form of dyssomnias and cognitive disorders in patients receiving chemotherapy.Materials and methods. The work was conducted in the chemotherapy department and was based on the results of the examination of 50 women undergoing chemotherapy courses with a diagnosis of malignant breast neoplasm. The study sample included women whose history excluded conditions that independently caused various disorders of the sleep process and cognitive impairment. The women ranged in age from 37 to 58 years, had no history of drug or alcohol dependence and no history of traumatic brain injury. All the patients were divided into 3 groups according to the number of chemotherapy courses (group I – up to 10 courses, group II – from 10 to 19 courses, group III – from 20 courses and more).Results and discussion. A tendency to worsening of insomniac disorders according to ISI was revealed in patients of the second and third groups in comparison with the first group (p > 0.05). The analysis of cognitive disorders severity values according to the MMSE scale similarly did not reveal reliable differences between the groups (p > 0.05), and there was a tendency for MMSE values to decrease with the increase in the number of chemotherapy courses. When calculating the correlation between the results of ISI and MMSE, we obtained an inverse high strength relationship (ρ = -0.8715). In other words, the more pronounced was the patient’s problem with the sleep process, the less she scored on the MMSE scale (more pronounced cognitive impairment).Conclusions. The results of this study will add to the data available in the scientific literature on the effect of cytostatic drugs on the CNS and provocation of encephalopathy with insomniac and cognitive disorders. The data obtained will be useful for oncologists, neurologists, rehabilitologists and specialists working with oncology patients.

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Functional changes in the sleep-wake cycle after experimental traumatic brain injury

Cited by 2 publications

References 25 publications

Insomniac disorders in patients with traumatic brain injury complicated with subdural hematoma

Insomniac disorders in patients with traumatic brain injury complicated with subdural hematoma

Insomniac and cognitive disorders as a manifestation of encephalopathy during chemotherapy

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