Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2

He, Xuelian; Leow, Koon-Yeow; Yang, Hongyuan; Heng, Chew-Kiat

doi:10.1016/j.gene.2015.04.061

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…showed that, in humans, three ACAT2 polymorphisms, 41A>G (Glu>Gly), 734C>T (Thr>Ile), and IVS4‐57_58 ins48 bp (D/I), associate with plasma lipid levels and coronary artery disease (CAD) susceptibility, but that their effects were not consistent across genders and ethnic groups. In a further study, the enzymatic activity of mutant Glu(14)Gly was found approximately two times higher than the wild‐type activity and was associated to plasma lipid levels and CAD risk . ACAT2 expression is restricted to the small intestine and liver, and its deficiency reduces cholesterol absorption rendering mice resistant to diet‐induced hypercholesterolemia, gallstone formation, and atherosclerosis …”

Section: Fatmentioning

confidence: 89%

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

Walther

Lett

Bordoni

et al. 2019

Molecular Nutrition Food Res

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Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.

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Section: Fatmentioning

confidence: 89%