2023
DOI: 10.1007/s12144-023-04312-x
|View full text |Cite
|
Sign up to set email alerts
|

Functional connectivity abnormalities of brain networks in obsessive–compulsive disorder: a systematic review

Abstract: Obsessive-compulsive disorder (OCD) is characterized by cognitive abnormalities encompassing several executive processes. Neuroimaging studies highlight functional abnormalities of executive fronto-parietal network (FPN) and default-mode network (DMN) in OCD patients, as well as of the prefrontal cortex (PFC) more specifically. We aim at assessing the presence of functional connectivity (FC) abnormalities of intrinsic brain networks and PFC in OCD, possibly underlying specific computational impairments and cli… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(2 citation statements)
references
References 182 publications
(396 reference statements)
0
2
0
Order By: Relevance
“…Based on this evidence, our finding of increased right IFG-SPL coupling in individuals with ED may reflect the generation of motor representations, as well as the preparation of subsequent motor actions and their monitoring ( Loffler, Haggard, & Bode, 2020 ; Si, Rowe, & Zhang, 2021 ). Notably, increased fronto-parietal resting-state connectivity has repeatedly been observed in obsessive-compulsive disorder ( Fornaro & Vallesi, 2023 ). IFG-SPL hyperconnectivity may thus underlie a lack of cognitive control over compulsive behaviours, in this case, exercise.…”
Section: Discussionmentioning
confidence: 99%
“…Based on this evidence, our finding of increased right IFG-SPL coupling in individuals with ED may reflect the generation of motor representations, as well as the preparation of subsequent motor actions and their monitoring ( Loffler, Haggard, & Bode, 2020 ; Si, Rowe, & Zhang, 2021 ). Notably, increased fronto-parietal resting-state connectivity has repeatedly been observed in obsessive-compulsive disorder ( Fornaro & Vallesi, 2023 ). IFG-SPL hyperconnectivity may thus underlie a lack of cognitive control over compulsive behaviours, in this case, exercise.…”
Section: Discussionmentioning
confidence: 99%
“…It is also possible that symptom-provoking stimuli induce obsessions that overload OCD patients’ inhibition and limit patients’ ability to inhibit their responses [ 13 , 62 ]. On a neurobiological level, patients’ reduced ability to inhibit responses to symptom-provoking stimuli in external tasks (like the stop signal task) may reflect interference in downregulating their default mode network—a large-scale brain network associated with self-referential processes [ 63 , 64 , 65 ]. Taken together, the above studies combined with the findings of the current study provide support for the notion that symptom-provocation is associated with impaired inhibition in individuals with OCD, a mechanism which may underlie the vicious cycle of obsessions/anxiety and compulsions in OCD.…”
Section: Discussionmentioning
confidence: 99%