Functional Dendritic Coatings for Biomedical Implants

Thomas, Jobin; Yadav, Shweta; Satija, Jitendra; Agnihotri, Shekhar

doi:10.1007/978-981-15-9920-0_6

Cited by 3 publications

(3 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further examples deriving from nanomedicine [ 93 , 94 ] include cancer diagnosis [ 95 , 96 ] and therapy [ 97 , 98 ], gene transfection [ 99 , 100 , 101 ], biosensors [ 102 , 103 ], magnetic resonance and bioimaging [ 104 , 105 ] and theranostics [ 106 , 107 ]. Important research is also performed in other clinical fields, such as the treatment of central nervous system conditions [ 108 , 109 ], therapy for inflammatory diseases, such as rheumatoid arthritis [ 110 , 111 ], antimicrobial coatings for orthopedical implants [ 112 , 113 ], and antigen mimicry for vaccinations [ 114 ]. Tissue engineering appears to be the discipline best suited to the properties of bio-dendritic polymers [ 115 , 116 , 117 , 118 ].…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

et al. 2023

View full text Add to dashboard Cite

The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Perhaps the most important implementations are those that involve interactions with the regenerative mechanisms of cells. In general, they are non-toxic or exhibit very low toxicity. Thus, they allow unhindered and, in many cases, faster cell proliferation, a property that renders them ideal materials for tissue engineering scaffolds. Their resemblance to proteins permits the synthesis of derivatives that mimic collagen and elastin or are capable of biomimetic hydroxy apatite production. Due to their distinctive architecture (core, internal branches, terminal groups), dendritic polymers may play many roles. The internal cavities may host cell differentiation genes and antimicrobial protection drugs. Suitable terminal groups may modify the surface chemistry of cells and modulate the external membrane charge promoting cell adhesion and tissue assembly. They may also induce polymer cross-linking for healing implementation in the eyes, skin, and internal organ wounds. The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will also be exposed to the incorporation of methods for establishment of biomaterials, functionalization strategies, and the synthetic paths for organizing assemblies from biocompatible building blocks and natural metabolites.

show abstract

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Silver nanoflowers have been employed for use as biosensors [ 25 ], nanodevices [ 26 ], and SERS substrates [ 27 ], displaying optimized properties compared to their nanoparticles. On the other hand, dendritic nanostructures have gained great attention due to their antibacterial properties as antibacterial coatings for medical implants [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Response Evaluation of Human Fetal Osteoblast Cells and Bacterial Cells on Fractal Silver Dendrites for Bone Tissue Engineering

et al. 2023

View full text Add to dashboard Cite

Prosthetic joint replacement is the most widely used surgical approach to repair large bone defects, although it is often associated with prosthetic joint infection (PJI), caused by biofilm formation. To solve the PJI problem, various approaches have been proposed, including the coating of implantable devices with nanomaterials that exhibit antibacterial activity. Among these, silver nanoparticles (AgNPs) are the most used for biomedical applications, even though their use has been limited by their cytotoxicity. Therefore, several studies have been performed to evaluate the most appropriate AgNPs concentration, size, and shape to avoid cytotoxic effects. Great attention has been focused on Ag nanodendrites, due to their interesting chemical, optical, and biological properties. In this study, we evaluated the biological response of human fetal osteoblastic cells (hFOB) and P. aeruginosa and S. aureus bacteria on fractal silver dendrite substrates produced by silicon-based technology (Si_Ag). In vitro results indicated that hFOB cells cultured for 72 h on the Si_Ag surface display a good cytocompatibility. Investigations using both Gram-positive (S. aureus) and Gram-negative (P. aeruginosa) bacterial strains incubated on Si_Ag for 24 h show a significant decrease in pathogen viability, more evident for P. aeruginosa than for S. aureus. These findings taken together suggest that fractal silver dendrite could represent an eligible nanomaterial for the coating of implantable medical devices.

show abstract

“…Further examples deriving from nanomedicine include cancer diagnosis [75][76] and therapy [77][78], gene transfection [79][80][81], biosensors [82][83], magnetic resonance, and bioimaging [84][85], theranostics [86][87]. Important research is also performed in other clinical fields for instance the treatment of central nervous system conditions [88][89] therapy of inflammatory diseases for example rheumatoid arthritis [90][91], antimicrobial coatings for orthopedical implants [92][93], and antigen mimicry for vaccinations. The disciple thought that seems best fitting to the properties of bio-dendritic polymers, is tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers Applications in Tissue Engineering

Arkas¹,

Vardavoulias²,

Kythreoti³

et al. 2022

Preprint

View full text Add to dashboard Cite

The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Among them, perhaps the most important are those that involve interactions with the regenerative mechanisms of cells. Dendritic polymers due to their distinctive architecture may play a multitude of roles such as protein biomimicry (collagen, elastin, hydroxy apatite production), gene and drug delivery (cell differentiation, antimicrobial protection), surface chemistry and charge modulation (adhesion to cells and tissues), polymer cross-linking (eye, skin and internal organ wound healing). The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will be also exposed to the incorporation methods to established biomaterials such as scaffolds, the functionalization strategies, and the synthetic paths for the assembly from biocompatible building blocks and natural metabolites.

show abstract

Functional Dendritic Coatings for Biomedical Implants

Cited by 3 publications

References 75 publications

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution

Biological Response Evaluation of Human Fetal Osteoblast Cells and Bacterial Cells on Fractal Silver Dendrites for Bone Tissue Engineering

Dendritic Polymers Applications in Tissue Engineering

Contact Info

Product

Resources

About