Functional Esophageal Disorders

Galmiche, Jean Paul; Clouse, Ray E.; Bálint, András; Cook, Ian J.; Kahrilas, Peter J.; Paterson, William G.; Smout, A. J. P. M.

doi:10.1053/j.gastro.2005.08.060

Cited by 468 publications

(391 citation statements)

References 49 publications

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“…3 Globus sensation (which has also been referred to as globus pharyngeus and globus hystericus) usually presents during adolesence or early adulthood, most often reported in young to middle aged women. The disorder may be severe or even life threatening.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Tuberculosis in a 9 Years Old Girl Presented with Globus Sensation: Case Report

Şen¹,

Bal²,

Yildiz³

et al. 2017

Turkiye Klinikleri J Case Rep

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Section: Discussionmentioning

confidence: 99%

Pulmonary Tuberculosis in a 9 Years Old Girl Presented with Globus Sensation: Case Report

Şen¹,

Bal²,

Yildiz³

et al. 2017

Turkiye Klinikleri J Case Rep

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“…6 Patients usually give long history and different mode of treatment. Condition has a tendency to recur in spite of long time intermittent treatment.…”

Section: Discussionmentioning

confidence: 99%

Study the effect of osteopathic manipulation treatment in globus pharyngeus patients

Baisakhiya¹,

Goyal²,

Singh³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: This study evaluates the outcome of osteopathic manipulation in the patients with globus pharyngeus.Methods: The study comprised of 50 patients with globus pharyngeus. All cases were provided major body diaphragms release namely pelvic diaphragm, abdominal diaphragm, thoracic outlet release, hyoid release, gastroesophageal junction release and sphenoid basilar junction generalized release in some selected cases as per their symptoms. Patients were treated 2 times in a week for 3 weeks. Results: Results were analyzed on the basis of patient’s satisfaction and improvement in the symptoms on regular basis after 2 wks. Visual analogue score (VAS) and clinical assessment were used to see the quantum of satisfaction and overall symptoms. The mean VAS score of patients receiving OMT (MFR) with PPI was 6.23±0.43 and patient who required psychotherapy along with OMT (MFR) had the VAS score of 3.78±0.17 (p<0.05).Conclusions: The patients required multidisciplinary approach hyoid bone release and other osteopathic manipulations, anti-reflux and antipsychotic treatment. The patients having psychological symptoms requiring antipsychotic drugs were found to be least respondent to the treatment. Patients having associated GERD showed a good response to the treatment and their dependency on drugs decreased following the OMT. The best response was seen in patients having no associated ailment and received OMT (MFR).

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“…One should not forget to consider the less frequent hypothesis of achalasia and gastroparesis, and more often, functional pyrosis caused by visceral hypersensitivity, which is treated with pain modulators such as tricyclic antidepressants and serotonin reuptake blockers in low doses (10) . Figure 2 shows the clinical algorithm for the main possibilities of refractory GERD.…”

Section: Discussionmentioning

confidence: 99%

“…Of these functional pyrosis is relatively more frequent, being defined as the presence of heartburn episodes occurring in the absence of gastroesophageal reflux, motility alterations or structural morphological abnormalities. It is caused by increased esophageal sensitivity and therefore, esophageal perception to the presence of acid (10) . The functional course of visceral hypersensitivity may occur in association with organic diseases such as GERD itself and in these cases, the clinical condition of the latter can be very intense.…”

Section: Functional Pyrosismentioning

confidence: 99%

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Refractory gastroesophageal reflux disease

Moraes-Filho

2012

Arq. Gastroenterol.

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-Context -Gastroesophageal reflux disease (GERD) is a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Its pathophysiology, diagnosis and treatment have frequently been analyzed but it is interesting to review some aspects of the GERD refractory patients to the proton pump inhibitors treatment. The treatment encompasses behavioral measures and pharmacological therapy. The majority of the patients respond well to proton pump inhibitors treatment but 20%-42% of them may not do so well. Patients who are unresponsible to 4-8 weeks' treatment with proton pump inhibitors (omeprazole, pantoprazole, rabeprazole, lansoprazole, esomeprazole, pantoprazole-Mg) might have so-called refractory GERD. Results -In some cases the patients are not real refractory because either they do not have GERD or the disease was not correctly treated, but the term refractory is still employed. Although debatable, the Brazilian GERD Consensus based upon evidences recommends as first step in the diagnosis, the upper digestive endoscopy to exclude the diagnosis of peptic ulcer and cancer and in some cases identify the presence of esophageal mucosa erosions. Conclusions -The main causes of the so-called refractory GERD are: (1) functional heartburn; (2) low levels of adherence to proton pump inhibitors treatment; (3) inadequate proton pump inhibitors dosage; (4) wrong diagnosis; (5) co-morbidities and pill-induced esophagitis; (6) genotypic differences; (7) nonacid gastroesophageal reflux; (8) autoimmune skin diseases; (9) eosinophilic esophagitis. HEADINGS -Gastroesophageal reflux, drug therapy. Proton pump inhibitors.

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Functional Esophageal Disorders

Cited by 468 publications

References 49 publications

Pulmonary Tuberculosis in a 9 Years Old Girl Presented with Globus Sensation: Case Report

Pulmonary Tuberculosis in a 9 Years Old Girl Presented with Globus Sensation: Case Report

Study the effect of osteopathic manipulation treatment in globus pharyngeus patients

Refractory gastroesophageal reflux disease

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