Functional Evaluation of the Reusable JuniorSTAR<sup>®</sup> Half-Unit Insulin Pen

Klonoff, David C.; Nayberg, Irina; Rabbone, Ivana; Domenger, Catherine; Stauder, Udo; Oualali, Hamid; Danne, Thomas

doi:10.1177/1932296815569246

Cited by 6 publications

(8 citation statements)

References 16 publications

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“…Insulin pens are more accurate, user friendly (with less fear of injections), and associated with low pain when used with short and fine needles. 8 , 9 , 24 – 26 …”

Section: Current Insulin-delivery Methods For Children and Aldolescenmentioning

confidence: 99%

“…Insulin pens are more accurate, user friendly (with less fear of injections), and associated with low pain when used with short and fine needles. 8,9,[24][25][26] NovoPen Echo® (NovoNordisk A/S, Bagsvaerd, Denmark) has merged two features, memory function, and half-unit increments dosing. It is a user-friendly, long-lasting insulin pen tailored for the pediatric population.…”

Section: Vial and Syringementioning

confidence: 99%

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Insulin-delivery methods for children and adolescents with type 1 diabetes

Zuberi

Sauli

Liu

et al. 2020

Therapeutic Advances in Endocrinology

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Efforts directed toward restoring normal metabolic levels by mimicking the physiological insulin secretion, thereby ensuring safety, efficacy, minimal invasiveness and conveniences, are of great significance in the management of type 1 diabetes among children and adolescents. Regardless of the various technologies being discovered in addressing invasiveness and enhancing medication adherence in the management of type 1 diabetes, yet limited success had been observed among children and adolescents. The multiple daily subcutaneous insulin injections route using vial and syringe, and occasionally insulin pens, remain the most predictable route for insulin administration among children and adolescents. However, this route has been associated with compromised patient compliance, fear of injections and unacceptability, resulting in poor glycemic control, which promote the demand for alternative routes of insulin administration. Alternative routes for delivering insulin are being investigated in children and adolescents with type 1 diabetes; these include the hybrid closed-loop ‘artificial pancreas’ system, oral, inhalation, intranasal routes, and others. This review article explores the current advances in insulin-delivery methods that address the needs of children and adolescents in the treatment of type 1 diabetes.

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“…Insulin pens are more accurate, user friendly (with less fear of injections), and associated with low pain when used with short and fine needles. 8 , 9 , 24 – 26 …”

Section: Current Insulin-delivery Methods For Children and Aldolescenmentioning

confidence: 99%

Section: Vial and Syringementioning

confidence: 99%

Insulin-delivery methods for children and adolescents with type 1 diabetes

Zuberi

Sauli

Liu

et al. 2020

Therapeutic Advances in Endocrinology

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“…This is in clear contrast to numerous publications about the accuracy of insulin delivery via insulin pens. [60][61][62][63][64][65][66] From a clinical point of view it is of high relevance to know that the intended amount of insulin is truly being delivered to the patient using CSII. It is a special advantage of CSII that very small amounts of insulin can be delivered, but they must be released precisely.…”

Section: Accuracy Of Bolusesmentioning

confidence: 99%

Boluses in Insulin Therapy

Ziegler¹,

Freckmann

Heinemann

2016

J Diabetes Sci Technol

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Giving a bolus is one major part in multiple dose insulin therapy (MDI) along with basal insulin substitution. To adjust the bolus optimally, different factors like carbohydrate content and composition of the meal, correction factors, and timing have to be considered. Advances in technologies like bolus advisors can assist the patients but still there a several open questions and technical challenges regarding boluses. This commentary provides an opportunity to address several of the above-mentioned factors influencing the result of bolusing. It shall draw attention to those factors and address the current opportunities, for example, continuous subcutaneous insulin infusion (CSII), as well as the need for further studies which can help to improve diabetes insulin therapy by means of the correct use of boluses.

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“… 9 , 25 , 26 Certain adults may also have lower dosing requirements, including elderly patients and T1D patients with a high level of physical activity or high insulin sensitivity. 27 - 29 Pen devices capable of delivering accurate, half-unit increments of insulin are available as an option for these patients, 30 including JuniorSTAR® (Sanofi S.A., Gentilly, France; JrS), 31 , 32 NovoPen Echo® (Novo Nordisk, A/S, Bagsværd, Denmark; NPE), 33 - 36 and HumaPen® Luxura™ HD (Eli Lilly and Company, Indianapolis, IN, USA; HPLHD). 37 , 38 All are reusable pens with a dose range of 1 to 30 units (JrS) or 0.5 to 30 units (NPE and HPLHD).…”

mentioning

confidence: 99%

“… 37 , 38 All are reusable pens with a dose range of 1 to 30 units (JrS) or 0.5 to 30 units (NPE and HPLHD). 32 , 36 , 37 …”

mentioning

confidence: 99%

Dose Accuracy, Injection Force, and Usability Assessment of a New Half-Unit, Prefilled Insulin Pen

Kappes

Kershner

Morwick

et al. 2017

J Diabetes Sci Technol

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Background:This study examines the utility of the first prefilled, rapid-acting insulin pen that can be dialed in half-unit increments. Dose accuracy and injection force were examined through a series of design-verification tests, and usability was established by human factors validation testing.Methods:Devices were tested for dose accuracy at 3 different doses and temperatures and under free fall, vibration, and cold storage conditioning. Injection force was measured at the maximum dose (30 units). Both experiments used the same semiautomated testing system. Usability was validated in a human factors simulated-use study that included 60 participants (patients with type 1 or type 2 diabetes [aged 10-79 years], adult caregivers, and health care providers).Results:The pen met the International Organization for Standardization (ISO) 11608-1:2014 requirements for dose accuracy at all settings and conditions tested. Furthermore, all individual results were within the ISO specification limits. Mean injection force across temperature settings ranged from 9.25 to 10.85 N at the highest dose. The usability validation study confirmed that use-related risks were reduced to the extent possible and that additional modifications were not likely to afford further reductions.Conclusions:The results from these studies demonstrated accurate dosing over the dose range (0.5-30 units) at different temperatures and conditions with an injection force that should accommodate the intended users. Use safety and usability in patients with diabetes, caregivers, and health care professionals were validated. The added convenience of this new half-unit, prefilled pen may ease the burden of diabetes management for patients who require smaller incremental dosing.

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Functional Evaluation of the Reusable JuniorSTAR^® Half-Unit Insulin Pen

Abstract: Together with results from a previously reported usability survey, these results show that the JuniorSTAR reusable, half-unit pen is a lightweight and accurate device for insulin delivery with a dialing torque and injection force suitable for young people with type 1 diabetes.

Cited by 6 publications

References 16 publications

Insulin-delivery methods for children and adolescents with type 1 diabetes

Insulin-delivery methods for children and adolescents with type 1 diabetes

Boluses in Insulin Therapy

Dose Accuracy, Injection Force, and Usability Assessment of a New Half-Unit, Prefilled Insulin Pen

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Product

Resources

About

Functional Evaluation of the Reusable JuniorSTAR® Half-Unit Insulin Pen

Abstract: Together with results from a previously reported usability survey, these results show that the JuniorSTAR reusable, half-unit pen is a lightweight and accurate device for insulin delivery with a dialing torque and injection force suitable for young people with type 1 diabetes.

Cited by 6 publications

References 16 publications

Insulin-delivery methods for children and adolescents with type 1 diabetes

Insulin-delivery methods for children and adolescents with type 1 diabetes

Boluses in Insulin Therapy

Dose Accuracy, Injection Force, and Usability Assessment of a New Half-Unit, Prefilled Insulin Pen

Contact Info

Product

Resources

About

Functional Evaluation of the Reusable JuniorSTAR^® Half-Unit Insulin Pen