Functional evidence for different roles of GABAA and GABAB receptors in modulating mouse gastric tone

Rotondo, Alessandra; Serio, Rosa; Mulè, Flavia

doi:10.1016/j.neuropharm.2010.01.004

Cited by 16 publications

(18 citation statements)

References 28 publications

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“…GABAergic cells in the gut modulate both motor and secretory activity as well as GI inflammation (Auteri et al , 2015). In mammals, GABA increases gastric tone by directly modulating intrinsic cholinergic neurons so a loss of such cells could promote gastric relaxation (Rotondo et al , 2010). GABAergic neurons are widely distributed in the chicken gizzard and the duodenum (Saffrey et al , 1983; Gabriel et al , 1990).…”

Section: The Enteric Nervous System (Ens)mentioning

confidence: 99%

The pathogenesis of proventricular dilatation disease

Tizard

Shivaprasad

Guo

et al. 2016

Anim. Health. Res. Rev.

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Bornaviruses cause neurologic diseases in several species of birds, especially parrots, waterfowl and finches. The characteristic lesions observed in these birds include encephalitis and gross dilatation of the anterior stomach - the proventriculus. The disease is thus known as proventricular dilatation disease (PDD). PDD is characterized by extreme proventricular dilatation, blockage of the passage of digesta and consequent death by starvation. There are few clinical resemblances between this and the bornaviral encephalitides observed in mammals. Nevertheless, there are common virus-induced pathogenic pathways shared across this disease spectrum that are explored in this review. Additionally, a review of the literature relating to gastroparesis in humans and the control of gastric mobility in mammals and birds points to several plausible mechanisms by which bornaviral infection may result in extreme proventricular dilatation.

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Section: The Enteric Nervous System (Ens)mentioning

confidence: 99%

The pathogenesis of proventricular dilatation disease

Tizard

Shivaprasad

Guo

et al. 2016

Anim. Health. Res. Rev.

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“…Moreover, independent of innervation by the central nervous system, peripheral GABA B receptor activation induces TTX- and atropine-sensitive gastric contractility in vitro (Rotondo et al, 2010), suggesting that baclofen locally increases gastric tone through activation of intrinsic cholinergic neurons. Not unexpectedly then, GABA B receptors have been shown to regulate gastric emptying (in mouse; Symonds et al, 2003).…”

Section: Gabab Receptors and Gastrointestinal Functionmentioning

confidence: 99%

A Gut Feeling about GABA: Focus on GABAB Receptors

Hyland¹,

Cryan²

2010

Front. Pharmacol.

158

121

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γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the body and hence GABA-mediated neurotransmission regulates many physiological functions, including those in the gastrointestinal (GI) tract. GABA is located throughout the GI tract and is found in enteric nerves as well as in endocrine-like cells, implicating GABA as both a neurotransmitter and an endocrine mediator influencing GI function. GABA mediates its effects via GABA receptors which are either ionotropic GABAA or metabotropic GABAB. The latter which respond to the agonist baclofen have been least characterized, however accumulating data suggest that they play a key role in GI function in health and disease. Like GABA, GABAB receptors have been detected throughout the gut of several species in the enteric nervous system, muscle, epithelial layers as well as on endocrine-like cells. Such widespread distribution of this metabotropic GABA receptor is consistent with its significant modulatory role over intestinal motility, gastric emptying, gastric acid secretion, transient lower esophageal sphincter relaxation and visceral sensation of painful colonic stimuli. More intriguing findings, the mechanisms underlying which have yet to be determined, suggest GABAB receptors inhibit GI carcinogenesis and tumor growth. Therefore, the diversity of GI functions regulated by GABAB receptors makes it a potentially useful target in the treatment of several GI disorders. In light of the development of novel compounds such as peripherally acting GABAB receptor agonists, positive allosteric modulators of the GABAB receptor and GABA producing enteric bacteria, we review and summarize current knowledge on the function of GABAB receptors within the GI tract.

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“…Moreover, many substances, including hormones, have been reported to exert a modulatory action on the nitrergic neurotransmission further underlying the importance of this innervation in the control of GI motility [ 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: The Control Of Gi Motilitymentioning

confidence: 99%

Nitric Oxide: From Gastric Motility to Gastric Dysmotility

Idrizaj

Traini

Vannucchi

et al. 2021

IJMS

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It is known that nitric oxide (NO) plays a key physiological role in the control of gastrointestinal (GI) motor phenomena. In this respect, NO is considered as the main non-adrenergic, non-cholinergic (NANC) inhibitory neurotransmitter responsible for smooth muscle relaxation. Moreover, many substances (including hormones) have been reported to modulate NO production leading to changes in motor responses, further underlying the importance of this molecule in the control of GI motility. An impaired NO production/release has indeed been reported to be implicated in some GI dysmotility. In this article we wanted to focus on the influence of NO on gastric motility by summarizing knowledge regarding its role in both physiological and pathological conditions. The main role of NO on regulating gastric smooth muscle motor responses, with particular reference to NO synthases expression and signaling pathways, is discussed. A deeper knowledge of nitrergic mechanisms is important for a better understanding of their involvement in gastric pathophysiological conditions of hypo- or hyper-motility states and for future therapeutic approaches. A possible role of substances which, by interfering with NO production, could prove useful in managing such motor disorders has been advanced.

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Functional evidence for different roles of GABAA and GABAB receptors in modulating mouse gastric tone

Cited by 16 publications

References 28 publications

The pathogenesis of proventricular dilatation disease

The pathogenesis of proventricular dilatation disease

A Gut Feeling about GABA: Focus on GABAB Receptors

Nitric Oxide: From Gastric Motility to Gastric Dysmotility

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